Arboviruses Worldwide: Epidemiology, Pathogenesis, and Global Health Challenges

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 903

Special Issue Editor


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Guest Editor
1. Virology Lab, Centro de Investigaciones Regionales “Dr. Hideyo Noguchi”, Universidad Autónoma de Yucatan (UADY), Merida, Mexico
2. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, USA
Interests: cell host and viral interactions; endothelial cell biology; virus pathogenesis; arboviruses; flavivirus; vector control
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Special Issue Information

Dear Colleagues,

Arboviruses, a diverse group of emerging and re-emerging viruses belonging to different viral families (e.g. Flaviviridae, Togaviridae, Peribunyaviridae) and mainly transmitted by arthropod vectors such as mosquitoes, midgets, and ticks, pose significant public health threats worldwide. Notable examples include dengue (DENV), Zika (ZIKV), chikungunya (CHIKV), Oropuche (ORV), yellow fever and West Nile (WNV) viruses. These viruses are responsible for millions of infections worldwide including a wide range of clinical manifestations, from mild febrile illnesses to severe and sometimes life-threatening neurological complications and hemorrhagic fevers. This Special Issue seeks to engage all manuscripts including major articles, reviews, brief reports, etc that address the epidemiology and transmission dynamics of arboviruses, emphasizing the role of climate change, urbanization, and global travel in their spread. The molecular mechanisms of viral pathogenesis and host immune responses are also discussed, alongside current diagnostic methods and therapeutic challenges. Furthermore, the Special Issue  looks to highlight the importance of vector control strategies, vaccine development, and public health interventions in mitigating the impact of arboviral diseases.

Dr. Henry Puerta-Guardo
Guest Editor

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Keywords

  • arboviruses
  • flavivirus
  • alphavirus
  • bunyavirus
  • vector-borne diseases
  • viral pathogenesis
  • vaccine development
  • public health
  • vector control strategies

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Published Papers (1 paper)

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Research

15 pages, 2127 KiB  
Article
The Incidence and Trends of Yellow Fever from 1990 to 2021 in Major Endemic Regions: A Systematic Analysis Based on the 2021 Global Burden of Disease Study
by Xinwei Wang, Bin Li, Baoren He, Xipeng Yan, Linbin Huang, Jinlian Li, Rongji Lai, Mingshuang Lai, He Xie, Qiuhong Mo and Limin Chen
Pathogens 2025, 14(6), 594; https://doi.org/10.3390/pathogens14060594 - 16 Jun 2025
Viewed by 663
Abstract
As a re-emerging disease, the worldwide burden and trends of yellow fever (YF) remain inadequately quantified. This study aims to assess the incidence of YF both globally and in major endemic regions from 1990 to 2021. Utilizing data from the Global Burden of [...] Read more.
As a re-emerging disease, the worldwide burden and trends of yellow fever (YF) remain inadequately quantified. This study aims to assess the incidence of YF both globally and in major endemic regions from 1990 to 2021. Utilizing data from the Global Burden of Disease (GBD) database, we evaluated the burden of YF. We employed an age–period–cohort model to assess the influence of age, period, and cohort on the incidence of YF from 1992 to 2021. A secondary data analysis based on GBD database showed the following: in 2021, there were 86,509 incident cases of YF. Between 1990 and 2021, the number of incident cases decreased by 74.7%, while the age-standardized incidence rate (ASIR) declined at an EAPC of −4.76% (95% confidence interval: −5.10 to −4.42). In 2021, the highest ASIRs of YF were observed in Western Sub-Saharan Africa, Central Sub-Saharan Africa, and Eastern Sub-Saharan Africa. The analysis of age effects indicates that children aged 5–10 years old exhibit the highest incidence rate. Both period and cohort effects demonstrated a decline in morbidity risk. The decomposition analysis identified epidemiological changes as the primary factor contributing to the global reduction in the YF burden. Despite considerable reduction in incidence, YF remains a significant public health threat in Sub-Saharan Africa. Full article
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