Immunopathogenesis of Tuberculosis: Potential Implications for Clinical Management
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".
Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 539
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mycobacterium tuberculosis elicits a strong immune response from the host to contain the infection. However, the immune-mediated inflammatory response also causes tissue damage, which contributes to the poor outcomes of some forms of the disease.
While susceptible pulmonary tuberculosis (TB) can be considered universally curable with the available treatment regimens, some extrapulmonary forms, such as TB of the central nervous system, still have unacceptable high mortality and disability rates. Insights into the negative impact of an exaggerated immune response on poor outcomes in TB arise from the beneficial effect of corticosteroids on the mortality of TB meningitis, and, to a lesser extent, in other forms of the disease. Likewise, the increased use of tumor necrosis factor-α antagonists and other host-directed therapies to control TB immune-mediated paradoxical reactions also contributes to the evidence on the field.
Recognizing the importance of research underway, this Special Issue of Pathogens will include papers that contribute to enhance our understanding and implications of the immunopathogenesis for the clinical management of TB—particularly, but not exclusively, of more unfavorable forms of the disease. Bench-to-bedside original research will be welcome.
Dr. Miguel Santin
Guest Editor
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Keywords
- immune response to tuberculosis
- immunopathogenesis of tuberculosis
- tuberculosis
- central nervous tuberculosis
- tuberculous meningitis
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