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Oral
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Advanced Dental Materials for Oral Rehabilitation
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Advanced Dental Materials for Oral Rehabilitation

A special issue of Oral (ISSN 2673-6373).

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 1284

Special Issue Editors

Dr. João Paulo Mendes Tribst

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Guest Editor
Department of Dental Materials, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands
Interests: dental implants; dental prosthodontics; finite element analysis; biomechanics; bond strength; fatigue; partial restorations; intraradicular retainer; prosthetic dentistry; fixed and removable prosthodontics; aesthetic dentistry; oral rehabilitation; digital dentistry; CAD/CAM technology; implant-supported dentures; full mouth rehabilitation; occlusion and bite analysis; dental materials for prosthodontics; denture design and fabrication; implant prosthodontics; prosthetic complications and management; maxillofacial prosthetics; prosthodontic treatment planning; prosthodontic maintenance and longevity; dental crowns and bridges; restorative dentistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Gabriel Kalil Rocha Pereira

E-Mail Website
Guest Editor
Prosthodontics Unit, Department of Restorative Dentistry and Post-Graduate Program in Oral Sciences, Faculty of Odontology, Federal University of Santa Maria, 1000 Roraima Av., T Street, Building 26F, Santa Maria, Brazil
Interests: prosthodontics; fixed and removable prosthodontics; oral rehabilitation; restorative dentistry; prosthodontic treatment planning; prosthodontic maintenance and longevity; aesthetic dentistry; digital dentistry; CAD/CAM technology; implant-supported prosthetics; full mouth rehabilitation; dental implants; crowns and bridges; denture design and fabrication; prosthetic complications and management; occlusion and bite analysis; dental materials for prosthodontics; biomechanics; bond strength; fatigue
Special Issues, Collections and Topics in MDPI journals
Dr. Rafaela Oliveira Pilecco

E-Mail
Guest Editor Assistant
Prosthodontics Unit, Department of Conservative Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Acess Gate K, Santa Cecília, Porto Alegre, Brazil
Interests: prosthodontics; fixed and removable prosthodontics; oral rehabilitation; restorative dentistry; prosthodontic treatment planning; prosthodontic maintenance and longevity; aesthetic dentistry; digital dentistry; CAD/CAM technology; implant-supported prosthetics; full mouth rehabilitation; dental implants; crowns and bridges; denture design and fabrication; prosthetic complications and management; occlusion and bite analysis; dental materials for prosthodontics; biomechanics; bond strength; fatigue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Advanced Dental Materials for Oral Rehabilitation", will explore the latest innovations and developments in dental materials that are crucial for enhancing oral rehabilitation practices. Our goal is to bring together cutting-edge research that focuses on the design, synthesis, and application of novel materials that improve both the functional and aesthetic outcomes of dental restorations and prosthetics. We seek to address significant challenges in oral rehabilitation, such as the durability of materials under mechanical stress, biocompatibility with oral tissues, and the seamless integration of materials with biological tissues. Contributions will delve into advanced dental materials, including high-strength ceramics, polymer composites, bioactive glasses, and smart materials that respond to environmental stimuli. Research on innovative bonding agents and surface treatments that enhance the adhesion and longevity of dental restorations is also highly encouraged. This Special Issue will highlight interdisciplinary approaches that combine insights from materials science, biomedical engineering, and clinical dentistry. We aim to develop materials that not only meet the necessary mechanical and aesthetic requirements but also promote tissue regeneration and minimize adverse reactions.

You may choose our Joint Special Issue in Materials.

Dr. João Paulo Mendes Tribst
Prof. Dr. Gabriel Kalil Rocha Pereira
Guest Editors

Dr. Rafaela Oliveira Pilecco
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Oral is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • dental materials
  • dental implants
  • polymers
  • ceramics
  • nanotechnology
  • smart materials
  • 3D printing
  • sustainable materials
  • eco-friendly materials

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

17 pages, 4416 KiB  
Article
Assessing the Genotoxic Impact of Ni-Cr Alloys in Dental Prosthodontics: A Preliminary Comparative Analysis with and Without Beryllium
by Florentina Caministeanu, Viorel Stefan Perieanu, Andrei Sabin Popa, Loredana Sabina Cornelia Manolescu, Andreea Angela Stetiu, Radu Catalin Costea, Mihai Burlibasa, Andrei Vorovenci, Raluca Mariana Costea, Cristina Maria Serbanescu, Andi Ciprian Dragus, Maria Antonia Stetiu, Madalina Adriana Malita and Liliana Burlibasa
Oral 2025, 5(2), 32; https://doi.org/10.3390/oral5020032 - 7 May 2025
Viewed by 82
Abstract
Objective: This study aims to evaluate cell proliferation capacity and micronuclei incidence in the presence of nickel–chromium (Ni-Cr)-based dental alloys, with and without the addition of beryllium (Be). The use of these alloys in dental prosthetics is widespread; however, the potential risks [...] Read more.
Objective: This study aims to evaluate cell proliferation capacity and micronuclei incidence in the presence of nickel–chromium (Ni-Cr)-based dental alloys, with and without the addition of beryllium (Be). The use of these alloys in dental prosthetics is widespread; however, the potential risks associated with their genotoxicity and cytotoxicity require further investigation. The study seeks to provide insight into the safety of these materials and their long-term impact on the health of both patients and dental professionals. Methods: The study was conducted through a comparative analysis of genotoxicity and cytotoxicity using human lymphocyte cultures exposed to two types of Ni-Cr-based dental alloys, one containing beryllium and the other without beryllium. The evaluations were performed according to the OECD Test No. 487 guideline, employing the micronucleus assay and cell proliferation assay. Lymphocytes were exposed to three different alloy concentrations (5 mg/mL, 10 mg/mL, and 20 mg/mL), and the effects on genetic material were analyzed microscopically. Descriptive statistics (mean, standard deviation, and variance) were calculated, and one-way ANOVA was used to assess statistical significance between groups, with a significance threshold of p < 0.05. Results: A significant increase in cytotoxicity and micronuclei incidence was observed in the samples containing beryllium compared to those without beryllium. Statistical analysis revealed significant differences (p < 0.001) between the test and control groups and between different concentrations. Additionally, a direct proportional relationship was noted between alloy concentration and the intensity of genotoxic effects. Microscopic analysis confirmed genetic material damage, indicating a potentially increased risk associated with the use of this type of dental material. Conclusions: The data obtained suggest that Ni-Cr-based dental alloys containing beryllium may present a significant risk of genotoxicity and cytotoxicity. Therefore, the selection of materials used in dental prosthetics should be based on solid scientific evidence, and the use of these alloys should be approached with caution. The study highlights the need for further research to better understand the long-term impact of these materials on human health. Full article
(This article belongs to the Special Issue Advanced Dental Materials for Oral Rehabilitation)
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12 pages, 2129 KiB  
Article
Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study
by Mahmoud M. Bakr, Mahmoud Al Ankily, Mohammed Meer and Mohamed Shamel
Oral 2025, 5(1), 19; https://doi.org/10.3390/oral5010019 - 13 Mar 2025
Viewed by 685
Abstract
Background/Objectives: Bioactive materials are gaining increased popularity as materials of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there is a significant gap in the literature about cementogenic ability of bioceramic repair materials on the periodontal [...] Read more.
Background/Objectives: Bioactive materials are gaining increased popularity as materials of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there is a significant gap in the literature about cementogenic ability of bioceramic repair materials on the periodontal ligament cells. The aim of the present study was to investigate the effect of bioceramic materials (Biodentine and Bio-C Repair) on the cementogenesis potential of the periodontal ligament stem cells (PDLSCs). Methods: PDLSCs were isolated using the enzymatic digestion approach from sound extracted teeth. Material extracts were prepared on rubber discs and immersed in fresh growth medium for 24 h at 37 °C. Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) was used to detect the mRNA expression levels of cementogenic markers cementum protein 1 (CEMP1), Cementum attachment protein (CAP), pathway markers transforming growth factor β1(TGF-β1), bone morphogenic protein 2 (BMP2), and inflammatory marker IL-6. Results: Both materials (Biodentine and Bio-C Repair) showed significantly higher gene expressions when compared to the control groups. The gene expression with Bio-C Repair significantly increased when compared with Biodentine, except for TGF-β1 expression, where both materials exhibited similar results. Conclusions: Bio-C Repair demonstrated increased gene expression of cementogenic markers compared to Biodentine under the tested conditions. Further in vivo studies are deemed necessary to translate the findings from this study into clinical practice. Full article
(This article belongs to the Special Issue Advanced Dental Materials for Oral Rehabilitation)
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