Advance in Gluten-Free Diet

Dear Colleagues,

The only effective and safe treatment of celiac disease (CD) and gluten-related disorders is a lifelong, strict exclusion of gluten—the so-called gluten-free diet (GFD). Although this treatment is highly successful, following a strict GFD causes difficulties to patients in social and working contexts. As a consequence, a strict adherence to the GFD is not so easy to achieve in some patients. These findings have led to an interest in drug development, either as an addition to the GFD or as a substitute. On the other hand, many subjects are following a GFD without a specific diagnosis, but, to date, no controlled studies support or exclude a positive health effect of a GFD. In addition, the increasing interest in the interaction between a GFD and microbiota can develop our understanding in the knowledge and management of gluten-related disorders. New insights into the GFD are an exciting scientific challenge for researchers.

Dr. Paolo Usai-Satta
Guest Editor

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