Irritable Bowel Syndrome and Gluten-Related Disorders
Abstract
:1. Introduction
2. Materials and Methods
3. IBS and CD
4. CD and IBS
5. IBS, Gluten, Wheat, and NCGS/NCWS
6. IBS and Gluten/Wheat-Free Diet
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Authors (Ref) | Study Design | Study Method | Participants | Results |
---|---|---|---|---|
Potter [31] | Population-based study | Multivariate analysis | 3115 | NCWS was associated with IBS (OR: 3.55) |
Fritscher–Ravens [34] | Prospective controlled study | Confocal endomicroscopy before and after wheat administration | 36 IBS | IEL and intervillous spaces increased after wheat endoscopic challenge |
Wu [35] | Double-blinded gluten challenge | Immuno-histochemistry by endoscopic biopsies | 27 IBS-D | Increased gut permeability after gluten challenge |
Elli [36] | Double-blinded trial | GFD and gluten challenge | 134 with functional disorders (77 IBS) | 14% of patients meet NCGS criteria |
Carroccio [37] | Double-blinded trial | Wheat-free diet and wheat challenge | 920 IBS | 70 IBS with NCWS |
Authors (Ref) | Study Design | Study Duration | Participants | Diet Methods | Results |
---|---|---|---|---|---|
Vasquez Roque [39] | RCT | 6 months | 45 IBS-D | GFD and gluten challenge | More bowel movements on gluten challenge |
Aziz [40] | Prospective study | 6 weeks | 41 IBS-D | GFD | Symptoms improved on GFD |
Zanwar [41] | DBP trial | 4 weeks | 60 IBS-D | GFD and gluten challenge | Symptoms worsened on gluten challenge |
Elli [36] | DBP trial | 3-week GFD, followed by 1-week gluten challenge | 77 IBS | GFD and gluten challenge | Symptoms improved in 71% of IBS (34% relapsed on gluten challenge) |
Roncoroni [42] | RCT | 21 days | 50 celiac patients with IBS symptoms | GFD-LFD | Better symptom impact in GFD-LFD than GFD alone |
Biesiekierski [30] | DBP trial | 2-week LFD, followed by 1 week low, high gluten or placebo | 37 IBS-NCGS | High and low gluten challenge | No gluten effect on IBS symptoms; wheat sensitivity hypothesized |
Carroccio [37] | DBP trial | 5 weeks | 276 IBS and wheat sensitivity | Wheat-free diet and wheat challenge | Asymptomatic on wheat-free diet and symptoms increased on wheat challenge |
Dionne [12] | Meta-analysis | Variable | 111 GFD 397 LFD | GFD and LFD | Low evidence on GFD in IBS |
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Usai-Satta, P.; Bassotti, G.; Bellini, M.; Oppia, F.; Lai, M.; Cabras, F. Irritable Bowel Syndrome and Gluten-Related Disorders. Nutrients 2020, 12, 1117. https://doi.org/10.3390/nu12041117
Usai-Satta P, Bassotti G, Bellini M, Oppia F, Lai M, Cabras F. Irritable Bowel Syndrome and Gluten-Related Disorders. Nutrients. 2020; 12(4):1117. https://doi.org/10.3390/nu12041117
Chicago/Turabian StyleUsai-Satta, Paolo, Gabrio Bassotti, Massimo Bellini, Francesco Oppia, Mariantonia Lai, and Francesco Cabras. 2020. "Irritable Bowel Syndrome and Gluten-Related Disorders" Nutrients 12, no. 4: 1117. https://doi.org/10.3390/nu12041117