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The Impact of Diet on Allergic Diseases Prevention in Early Life...
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The Impact of Diet on Allergic Diseases Prevention in Early Life and Beyond

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 12373

Special Issue Editors

Prof. Dr. Barbara Sozanska

E-Mail Website
Guest Editor
1st Department and Clinic of Paediatrics, Allergology and Cardiology, Wrocław Medical University, 50-367 Wrocław, Poland
Interests: asthma; allergy; allergic diseases; respiration disorders; inflammation; pulmonary medicine; prevention of allergic diseases; diet role on immune function in early life; unpasteurized milk influence on immunology
Dr. Catherine J. Andersen

E-Mail Website
Guest Editor
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Interests: HDL; lipoproteins; lipid metabolism; immune function; inflammation; functional foods; human nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrients can exert a variety of effects in allergic diseases, atopic eczema, and asthma. They modulate the development of the immune system, shape the quality and diversity of the human microbiome, and influence gene expression through epigenetic interactions. Food may be an allergen, exacerbating course of allergic diseases, but may also serve as a protective factor. Drinking unpasteurized milk reduces the risk of asthma, early exposure to potential allergenic peanuts is effective at preventing a peanut allergy, and high maternal intake of fish oil reduces the risk of persistent wheeze and asthma in children. These and other recent findings regarding the role of nutrients in the prevention of allergic diseases has opened a new treasure trove of possibilities.

The purpose of this Special Issue is to provide up-to-date insights into the possibilities of allergy prevention, including asthma, atopic eczema, food allergies, and allergic rhinitis, provided by diet modifications both in early life and later in life. Papers presenting the potential mechanism of prevention, the role of the microbiome, epigenetic interactions, and more are highly welcome. Original research in both human and animal models, as well as narrated and systematic reviews and meta-analyses, are also welcome.

Prof. Dr. Barbara Sozanska
Dr. Catherine J. Andersen
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergy
  • prevention
  • diet
  • immune system
  • early life
  • food allergy
  • asthma
  • allergic rhinitis
  • atopy
  • maternal diet
  • microbiome
  • micronutrients
  • macronutrients
  • milk
  • epidemiology
  • atopic eczema
  • food allergy

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Published Papers (4 papers)

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Research

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14 pages, 316 KiB  
Article
Spanish Pediatricians’ Positions Regarding Prevention, Diagnosis, Nutritional Management, and Challenges in Cow’s Milk Protein Allergy
by Rafael Martín-Masot, Juan José Díaz-Martín, Alicia Santamaría-Orleans and Víctor Manuel Navas-López
Nutrients 2023, 15(16), 3586; https://doi.org/10.3390/nu15163586 - 15 Aug 2023
Cited by 6 | Viewed by 2079
Abstract
Management of cow’s milk protein allergy (CMPA) can vary depending on the experience and area of expertise of the clinician responsible for the patient’s follow-up, which may or may not align with the recently published literature. To analyze the perspectives of Spanish pediatricians [...] Read more.
Management of cow’s milk protein allergy (CMPA) can vary depending on the experience and area of expertise of the clinician responsible for the patient’s follow-up, which may or may not align with the recently published literature. To analyze the perspectives of Spanish pediatricians on this topic, a survey was conducted. The survey aimed to determine the current opinions and attitudes of 222 primary care and hospital pediatricians toward CMPA prevention and nutritional management. Participating pediatricians completed the questionnaire, providing insights into their daily clinical practices, including access to testing, attitudes with respect to various aspects of CMPA diagnosis, prevention, oral food challenges, and treatment. The findings revealed that pediatricians generally agree on the use of extensively hydrolyzed formulas (eHFs) to prevent CMPA in high-risk atopic children, despite limited evidence supporting the widespread use of this practice. However, consensus was lacking regarding the utility of formulas with prebiotics and probiotics for expediting tolerance development. In most cases, pediatricians preferred eHFs for the nutritional management of CMPA, followed by hydrolyzed rice formulas (HRFs), with amino-acid-based formulas (AAFs) being the third option. Certain issues remained controversial among pediatricians, such as prevention methods, symptom assessment, and the role of probiotics. These variations in management approaches reflect the influence of clinician experience and area of expertise, underscoring the need for standardized guidelines in this field. Full article
(This article belongs to the Special Issue The Impact of Diet on Allergic Diseases Prevention in Early Life and Beyond)
14 pages, 4055 KiB  
Article
Novel Interactions of Myristic Acid and FADS3 Variants Predict Atopic Dermatitis among Indonesian Infants
by Conny Tanjung, Carla P. Harris, Hans Demmelmair, Sarah Dwitya, Zakiudin Munasir, Herawati Sudoyo, Marie Standl, Damayanti Rusli Sjarif and Berthold Koletzko
Nutrients 2022, 14(21), 4676; https://doi.org/10.3390/nu14214676 - 4 Nov 2022
Cited by 2 | Viewed by 2309
Abstract
Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the FADS1-3 [...] Read more.
Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the FADS1-3 gene cluster. Among 390 infants of the Indonesian ISADI study, GPL-FA were measured in umbilical plasma (P-0y) and in buccal cells at birth (B-0y), and again in buccal cells at AD onset or one year (B-1y). Prospective and cross-sectional associations with AD were assessed by logistic regression. Interactions of GPL-FA with 14 SNP were tested assuming an additive model. AD was diagnosed in 15.4% of participants. In B-1y, C18:2n-6 was inversely associated with AD; and positive associations were observed for C18:1n-9, C20:4n-6, C22:6n-3 and C20:4n-6/C18:2n-6. There were no prospective associations with AD, however, a significant interaction between the SNP rs174449 and B-0y C14:0 (myristic acid) was observed. This study indicates that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production, as well as higher C18:1n-9 levels. GPL-FA measured at birth do not predict later AD incidence; however, genotype interactions reveal novel effects of myristic acid, which are modified by a FADS3 variant. Full article
(This article belongs to the Special Issue The Impact of Diet on Allergic Diseases Prevention in Early Life and Beyond)
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Review

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29 pages, 1497 KiB  
Review
Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges
by Anna Dębińska and Barbara Sozańska
Nutrients 2023, 15(5), 1070; https://doi.org/10.3390/nu15051070 - 21 Feb 2023
Cited by 14 | Viewed by 4572
Abstract
Food allergy represents a growing public health and socio-economic problem with an increasing prevalence over the last two decades. Despite its substantial impact on the quality of life, current treatment options for food allergy are limited to strict allergen avoidance and emergency management, [...] Read more.
Food allergy represents a growing public health and socio-economic problem with an increasing prevalence over the last two decades. Despite its substantial impact on the quality of life, current treatment options for food allergy are limited to strict allergen avoidance and emergency management, creating an urgent need for effective preventive strategies. Advances in the understanding of the food allergy pathogenesis allow to develop more precise approaches targeting specific pathophysiological pathways. Recently, the skin has become an important target for food allergy prevention strategies, as it has been hypothesized that allergen exposure through the impaired skin barrier might induce an immune response resulting in subsequent development of food allergy. This review aims to discuss current evidence supporting this complex interplay between the skin barrier dysfunction and food allergy by highlighting the crucial role of epicutaneous sensitization in the causality pathway leading to food allergen sensitization and progression to clinical food allergy. We also summarize recently studied prophylactic and therapeutic interventions targeting the skin barrier repair as an emerging food allergy prevention strategy and discuss current evidence controversies and future challenges. Further studies are needed before these promising strategies can be routinely implemented as prevention advice for the general population. Full article
(This article belongs to the Special Issue The Impact of Diet on Allergic Diseases Prevention in Early Life and Beyond)
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10 pages, 279 KiB  
Review
The Impact of Dietary Intervention in Obese Children on Asthma Prevention and Control
by Hanna Sikorska-Szaflik, Joanna Połomska and Barbara Sozańska
Nutrients 2022, 14(20), 4322; https://doi.org/10.3390/nu14204322 - 15 Oct 2022
Cited by 5 | Viewed by 2361
Abstract
The prevalence of both asthma and obesity in the pediatric population is steadily increasing, and even the obese–asthma phenotypes are postulated. Obese children with asthma experience more asthma symptoms, more frequent exacerbations, and worse response to treatment; they also report a lower quality [...] Read more.
The prevalence of both asthma and obesity in the pediatric population is steadily increasing, and even the obese–asthma phenotypes are postulated. Obese children with asthma experience more asthma symptoms, more frequent exacerbations, and worse response to treatment; they also report a lower quality of life compared with lean asthmatics. Some of the etiological factors for asthma and obesity may overlap. Perhaps asthma and obesity share a common genetic and immunologic origin. Diet is a compelling modifiable factor in obesity and asthma prevention and control, although the relationship between these two diseases is certainly multifactorial. In this article, we analyze the impact of dietary intervention and weight loss in obese children on asthma prevention and control. Full article
(This article belongs to the Special Issue The Impact of Diet on Allergic Diseases Prevention in Early Life and Beyond)
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