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Nutrients
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Allergy in Pediatrics: Nutritional Prevention and Intervention
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Allergy in Pediatrics: Nutritional Prevention and Intervention

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 15 October 2026 | Viewed by 3558

Special Issue Editor

Prof. Dr. Barbara Sozanska

E-Mail Website
Guest Editor
1st Department and Clinic of Paediatrics, Allergology and Cardiology, Wrocław Medical University, 50-367 Wrocław, Poland
Interests: asthma; allergy; allergic diseases; respiration disorders; inflammation; pulmonary medicine; prevention of allergic diseases; diet’s role in immune function in early life; unpasteurized milk influence on immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is a growing body of evidence on the role of diet in the pathogenesis of allergic diseases in children. Dietary factors may also contribute to preventive strategies. The evidence is growing, but established knowledge about the role of specific nutritional intervention in atopy, allergies, and asthma development is still missing. Therefore, a better understanding of the role of diet in these diseases seems to be critical for achieving progress in reducing their incidence and morbidity. The purpose of this Special Issue is to provide up-to-date insights into the role of nutrition in allergy prevention and to search for intervention possibilities. Original research articles in both human and animal models, as well as narrated and systematic reviews and meta-analyses are highly welcome.

Prof. Dr. Barbara Sozanska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric allergy
  • prevention
  • nutrition
  • dietary interventions

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Published Papers (2 papers)

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Research

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19 pages, 6601 KB  
Article
Disentangling Gut Microbiome Alterations in Children with Cow’s Milk Allergy: Impact of Sex, Milk Elimination, and Family History of Allergies
by E. Daniel León, Dafni Moriki, Alejandro Artacho, Xavier Pons, Despoina Koumpagioti, Sophia Tsabouri, Kostas N. Priftis, Konstantinos Douros and M. Pilar Francino
Nutrients 2026, 18(3), 398; https://doi.org/10.3390/nu18030398 - 26 Jan 2026
Viewed by 1670
Abstract
Background: Children with cow’s milk allergy (CMA) present alterations in their gut microbiome, but any potential sex-dependency of these has not been addressed. Further, whether eliminating milk from children’s diet has similar effects on the gut microbiomes of boys and girls is [...] Read more.
Background: Children with cow’s milk allergy (CMA) present alterations in their gut microbiome, but any potential sex-dependency of these has not been addressed. Further, whether eliminating milk from children’s diet has similar effects on the gut microbiomes of boys and girls is also not known. Here, our main objective is to analyze how CMA and development of oral tolerance (DOT) to milk proteins affect the gut microbiota in female and male children. We also perform exploratory analyses to investigate whether milk elimination and/or a family history of allergies underlie sex-associated differences. Methods: We obtained 16S rRNA gene sequences of the intestinal microbiota of 32 children aged 5–12 years with CMA, of which 14 had active CMA and 18 had developed oral tolerance, along with 36 age-matched healthy controls (51.5% male). PERMANOVA and differential abundance analyses were employed to evaluate overall compositional differences and to identify bacteria varying between the groups. Results: The effects of CMA on the gut microbiome are more pronounced in girls, including female-specific decreases in bacteria potentially related to protection from allergy, such as Monoglobus and Anaerostipes. The girls’ microbiomes were also found to be more influenced by a family history of allergy, remaining farther from the healthy state upon DOT. In contrast, milk elimination affects more taxa in boys in the control group than in girls in the control group, although it alters global microbiome composition in both. In all, milk elimination and family history fail to explain most microbiome alterations observed in CMA, indicating that the latter are specifically linked to disease development. Conclusions: Gut microbiome alterations associated with CMA are sex-dependent, suggesting that sex-specific strategies, dietary and otherwise, may be more effective at modulating them toward healthier states. Full article
(This article belongs to the Special Issue Allergy in Pediatrics: Nutritional Prevention and Intervention)
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Review

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18 pages, 533 KB  
Review
Living with Food Allergy in Adolescence: The Nutritional and Psychological Impact of Allergen Avoidance
by Hanna Sikorska-Szaflik, Joanna Połomska and Barbara Sozańska
Nutrients 2026, 18(1), 56; https://doi.org/10.3390/nu18010056 - 23 Dec 2025
Viewed by 1377
Abstract
The prevalence of food allergy continues to rise worldwide. The allergen profile of affected individuals changes with age: milk, egg, wheat, and soy allergies are more common in early childhood and often resolve before adolescence, whereas peanut, tree nut, fish, and shellfish allergies [...] Read more.
The prevalence of food allergy continues to rise worldwide. The allergen profile of affected individuals changes with age: milk, egg, wheat, and soy allergies are more common in early childhood and often resolve before adolescence, whereas peanut, tree nut, fish, and shellfish allergies tend to persist and become more apparent in teenagers. The aim of this narrative review is to discuss the impact of food allergy and elimination diets on the nutritional status, psychological functioning, and quality of life of adolescents. Although an elimination diet remains the main way of treatment, it may lead to the risk of vitamin D, calcium, iron, and protein deficiencies, and potentially to growth disorders. In adolescents, irregular eating habits and poor adherence to dietary recommendations pose additional challenges. The psychological burden of living with food allergy include fear of accidental contact with the allergen, difficulties in peer relationships, and reduced quality of life, particularly in terms of social and emotional functioning. Lack of training in using an adrenaline autoinjector and embarrassment about its use are further risk factors in this age group. Optimal care for adolescents with food allergies requires a multidisciplinary approach, including an allergist, dietitian, and psychologist. Education, psychological support, and gradual development of self-management skills are crucial to improving the safety and quality of life of adolescents with food allergies. Further efforts by medical societies are warranted to advance the development of alternative therapeutic approaches for food allergy, including immunotherapy and biologic therapies, as well as to strengthen public health strategies for individuals affected by food allergies. Full article
(This article belongs to the Special Issue Allergy in Pediatrics: Nutritional Prevention and Intervention)
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