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The Relations between Nutrition and Infectious Diseases at the Epoch of Microbiota—2024 Update

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 December 2024) | Viewed by 964

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Guest Editor
Department of Odontostomatologic and Specialized Clinical Sciences, Sez-Biochimica, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy
Interests: nutrition; periodontal diseases/periodontitis; oxidative stress; nutrition; aging; mitochondrial function and diseases; berries (strawberry, blueberry, bilberry, cranberry, etc.); olive oil (dietary fats); honey; polyphenols; flavonoids; antioxidants; apoptosis
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Special Issue Information

Dear Colleagues,

Nutrition and human infectious diseases have always been intricately linked. Today, thanks to the next-generation sequencing technologies allowing scientists to identify specific interactions in microbial communities, the microbiota has been emerging as a crucial moderator in the complex interactions between food, our body and infectious diseases. Nutrition impacts the development of the human immune system, beginning from the embryonic stage. Additionally, the microbiota plays a fundamental role in the induction, training and function of the host immune system. Negative effects on the regular development of the immune system compromise its defense against pathogens. Likewise, if food has a microbial contamination, it can influence the emergence of infectious diseases (e.g., gastrointestinal infections), intestinal diseases (e.g., microbial diarrhea), food poisoning (botulism) and systemic infectious diseases (brucellosis and typhoid).

Moreover, malnutrition, including overnutrition and undernutrition, can increase the risk of infectious diseases, amplify the severity of an infection and impair the response to drug treatment. Finally, infectious diseases can increase malnutrition.

In this Special Issue, the mentioned aspects of the relationship between nutrition, infections and the emerging role of the microbiota will be presented. Insights into more promising approaches in the form of original research articles or reviews on all areas of nutrition and infectious disease with a special focus on microbiome, experimental designs and therapeutic approaches are welcome. 

Prof. Dr. Maurizio Battino
Guest Editor

Manuscript Submission Information

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Keywords

  • nutrition
  • infectious disease
  • microbiota
  • malnutrition
  • immune system

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Published Papers (1 paper)

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Review

17 pages, 564 KiB  
Review
The Interplay Between Nutrition and Microbiota and the Role of Probiotics and Symbiotics in Pediatric Infectious Diseases
by María Slöcker-Barrio, Jesús López-Herce Cid and María José Solana-García
Nutrients 2025, 17(7), 1222; https://doi.org/10.3390/nu17071222 - 31 Mar 2025
Viewed by 412
Abstract
The interplay between nutrition and infectious diseases has been a central theme in health sciences for the last decades due to its great impact on the pediatric population, especially in immunocompromised patients and critically ill children. As conventional treatment and the development of [...] Read more.
The interplay between nutrition and infectious diseases has been a central theme in health sciences for the last decades due to its great impact on the pediatric population, especially in immunocompromised patients and critically ill children. As conventional treatment and the development of antimicrobials for most infections standard treatment is either limited or not possible, alternative treatment options should be explored. Recent research shows that early enteral nutrition and nutritional supplements (such as probiotics and symbiotics) could have a pivotal role in promoting a healthy microbiome and subsequently preventing and improving outcomes for certain pediatric infectious diseases. However, understanding the specific mechanism of action and tailoring nutritional interventions remains a significant challenge. The optimal dose range for different probiotic strains and prebiotics and the most effective combination for each treatment indication needs further investigation and is yet to be defined. Additionally, in the era of personalized medicine, goal- and patient-directed treatment are key to optimizing and improving outcomes and minimizing potential complications and side effects, especially in complex and immunocompromised patients. The main objectives of this narrative review are 1. to explore the relationship and the complex interactions between microbiota and the human immune system; 2. to describe the influence of nutrition on infectious diseases; 3. to evaluate the impact of supplementation with probiotics and symbiotics in the prevention and treatment of the most relevant infections in children; and 4. to identify knowledge gaps and potential research priorities regarding the use of these supplements in pediatric patients. Full article
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