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Hypothalamic–Pituitary and Adipose Tissue Responses to the Effect of Resistin in Sheep: The Integration of Leptin and Resistin Signaling Involving a Suppressor of Cytokine Signaling 3 and the Long Form of the Leptin Receptor

1
Department of Animal Biotechnology, Laboratory of Biotechnology and Genomics, University of Agriculture in Krakow, 30-248 Krakow, Poland
2
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
*
Author to whom correspondence should be addressed.
In the Authors Opinion, Dorota A. Zieba and Weronika Biernat should be Considered as Equal First Authors of the Paper.
Nutrients 2019, 11(9), 2180; https://doi.org/10.3390/nu11092180
Received: 11 July 2019 / Revised: 14 August 2019 / Accepted: 6 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Leptin)
We hypothesized that resistin is engaged in the development of leptin central insensitivity/resistance in sheep, which is a unique animal model to explore reversible leptin resistance. Thirty Polish Longwool ewes, which were ovariectomized with estrogen replacement, were used. Treatments consisted of the intravenous injection of control (saline) or recombinant bovine resistin (rbresistin): control (Control; n = 10), a low dose of rbresistin (R1; 1.0 μg/kg body weight (BW); n = 10), and a high dose of rbresistin (R2; 10.0 μg/kg BW; n = 10). The studies were performed during short-day (SD) and long-day (LD) photoperiods. Leptin and resistin concentrations were determined. Expression levels of a suppressor of cytokine signaling (SOCS)-3 and the long form of the leptin receptor (LeptRb) were determined in selected brain regions, including in the anterior pituitary (AP), hypothalamic arcuate nucleus (ARC), preoptic area (POA), and ventro- and dorsomedial nuclei (VMH/DMH). The results indicate that resistin induced a consistent decrease in LeptRb (except in POA) and an increase in SOCS-3 expression during the LD photoperiod in all selected brain regions. In conclusion, the results demonstrate that the action of resistin appears to be strongly associated with photoperiod-driven changes in the leptin signaling pathway, which may underlie the phenomenon of central leptin resistance. View Full-Text
Keywords: leptin; leptin receptor; leptin resistance; photoperiod; resistin; sheep; SOCS-3 leptin; leptin receptor; leptin resistance; photoperiod; resistin; sheep; SOCS-3
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Zieba, D.A.; Biernat, W.; Szczesna, M.; Kirsz, K.; Misztal, T. Hypothalamic–Pituitary and Adipose Tissue Responses to the Effect of Resistin in Sheep: The Integration of Leptin and Resistin Signaling Involving a Suppressor of Cytokine Signaling 3 and the Long Form of the Leptin Receptor. Nutrients 2019, 11, 2180.

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