Special Issue "Application of Immunonutrient in Human Health and Disease "

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 30 November 2019.

Special Issue Editor

Prof. Dr. Ascensión Marcos
E-Mail Website
Guest Editor
ICTAN-CSIC Spanish National Research Council, 28040 Madrid, Spain
Interests: nutrients; bioactive compounds, probiotics, health, disease, microbiota–nutrition axis, lifestyle, humans

Special Issue Information

Dear Colleagues,

The study of Immunonutrition, which focuses on the interactions between nutrition and immunity, has significantly intensified during the last decades. This is a relevant field that has raised the interest of many health professionals. Indeed, there is a relevant number of papers showing different effects of diverse nutrients and bioactive compounds on immunological biomarkers.

This Special Issue deals with several examples of nutrients and food ingredients that have shown benefits for human health. Nowadays, there is a big concern about non-communicable diseases, mainly in industrialized countries. On the basis of the extremely high global burden of obesity around the world, the incidence of illnesses in humans might dramatically change with respect to the 2000s, from around 900 million overweight people and 400 million obese people, to an estimation of more than twice these figures for the next decade. This outcome means that a great number of subjects will be more prone to suffer from different health problems related to organs that are essential for life. Thus, it is necessary to promote research, innovation, and development in this area, acquiring more knowledge to improve human health.

Prof. Dr. Ascensión Marcos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrients
  • bioactive compounds
  • probiotics
  • health
  • disease
  • microbiota–nutrition axis
  • lifestyle
  • humans

Published Papers (2 papers)

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Research

Open AccessArticle
Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study
Nutrients 2019, 11(8), 1765; https://doi.org/10.3390/nu11081765 - 31 Jul 2019
Abstract
The fecal microbiota plays an important role in human health, and alterations in the microbiota–host interaction seem to be involved in the ageing process. Therefore, it is of interest to develop strategies for promoting a balanced microbiota in old age in order to [...] Read more.
The fecal microbiota plays an important role in human health, and alterations in the microbiota–host interaction seem to be involved in the ageing process. Therefore, it is of interest to develop strategies for promoting a balanced microbiota in old age in order to prevent the physiological and immune decline associated with age. However, the specific microbiota changes in the transition from adulthood to senescence are not yet well understood. Here we assessed the levels of some intestinal microorganisms and short chain fatty acids (SCFAs) across different age-groups. In total, 153 adults from four age groups (<50, 50–65, 66–80, and >80 years-old) were recruited; the levels of different bacterial groups in fecal samples were determined by quantitative polymerase chain reaction (qPCR), and those of SCFA by gas chromatography. Dietary information was collected by using a Food Frequency Questionnaire. The presence of the Bifidobacterium, Faecalibacterium, Bacteroides group, and Clostridium cluster XIVa decreased with age up to 66–80 years of age, with differences reaching statistical significance for the latter group. Interestingly, the levels of some of these microorganisms recovered in the very old age group (>80 years), with these older individuals presenting significantly higher counts of Akkermansia and Lactobacillus group than adults and the younger elderly. In addition, ageing was associated with a progressively and statistically significant reduction in the fecal concentrations of SCFAs. Dietary intakes also showed some statistically significant differences among the groups for some macro- and micronutrients. Moreover, associations of some microorganisms with age and macronutrients were also evidenced. Considering the role that fecal microbiota alterations may have in terms of impairing homeostasis and resilience, our results underline the importance of understanding the ageing and immunosenescence processes by including the microbiota perspective. Full article
(This article belongs to the Special Issue Application of Immunonutrient in Human Health and Disease )
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Open AccessArticle
GPP (Composition of Ganoderma lucidum Poly-saccharides and Polyporus umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice
Nutrients 2019, 11(7), 1480; https://doi.org/10.3390/nu11071480 - 28 Jun 2019
Abstract
Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly exhibit immunoregulation. However, the immune function of a polysaccharide composition consisting of GLP and PUP has not been studied. In this study, we developed a polysaccharide composition consisting [...] Read more.
Modern research has found that Ganoderma lucidum polysaccharides (GLP) and Polyporus umbellatus polysaccharides (PUP) mainly exhibit immunoregulation. However, the immune function of a polysaccharide composition consisting of GLP and PUP has not been studied. In this study, we developed a polysaccharide composition consisting of GLP and PUP in a ratio of 3:1 (named GPP). The immunoregulation of GPP was detected in RAW264.7 macrophages. Then, the acute oral toxicity of GPP and the effect of GPP on immunoregulation in mice was detected. The results showed that GPP enhanced the function of macrophage RAW264.7 cells through improving phagocytic ability, nitric oxide (NO) production and the mRNA expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF)-α. GPP belonged to the non-toxic grade in mice. Moreover, GPP significantly improved macrophage phagocytic function and the activity of natural killer (NK) cells after being administered to mice at a dose of 0, 3.6, 120, 360 mg/kg body weight (mg/kg BW) orally for 30 days. Taken together, these findings suggested that GPP moderately regulated immune function in mice, which contributes to the further development and utilization of GLP and PUP in immune function. Full article
(This article belongs to the Special Issue Application of Immunonutrient in Human Health and Disease )
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

  1. Title: Breast milk Lactobacillus probiotic strains modulate PBMC functionality in vitro
    Authors: Ignasi Azagra-Boronat1,2, Maria J. Rodríguez-Lagunas1,2, Parveen Yaqoob3, Francisco J. Pérez-Cano1,2
    Affiliations: 1Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona 08028, Spain 2Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet 08921, Spain. 3School of Chemistry, Nutritional and Food Sciences & Pharmacy, University of Reading, Reading, UK
  2. Title: The role of micronutrients in restoring resistance to infections
    Authors: Silvia Maggini1, Adeline Pierre1, Adrian Fritz Gombart2
    Affiliations: 1Bayer Consumer Care AG, 4002 Basel, Switzerland, 2Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States
  3. Title: Differences in inflammation and T cell-mediated function between young and older women with obesity
    Authors: Maria Carlota Dao1, Edward Saltzman1, Melissa Page2, Jillian Reece2, Tara Mojtahed1, Dayong Wu1, Simin Nikbin Meydani1
    Affiliations: 1Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States, 2Weight and Wellness Center at Tufts Medical Center, Boston, MA, United States
  4. Title: Molecules and cell fractions produced by probiotics and intestinal microorganisms with immunomodulatory activity
    Authors: Patricia Ruas-Madiedo, Susana Delgado, Lorena Ruiz, Abelardo Margolles, Borja Sánchez.
    Affiliation: Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC). Paseo Río Linares s/n. 33300 Villaviciosa, Asturias. Spain.
  5. Title: Potential of Moringa oleífera to improve glucose control for the prevention of diabetes and related metabolic alterations. Review of “in vivo” studies.
    Authors: Esther Nova, Noemí Redondo, Sonia Gómez-Martínez, Ligia Esperanza Díaz, Ascensión Marcos.
    Affiliation: Institute of Food Science and Nutrition (ICTAN). Spanish National Research Council (CSIC).
  6. Title: Lifestyle effects on the gut microbiota in healthy adults: a special focus on diet
    Authors: Esther Nova, Noemí Redondo, Sonia Gómez-Martínez, Ligia Esperanza Díaz, Ascensión Marcos.
    Affiliation: Institute of Food Science and Nutrition (ICTAN). Spanish National Research Council (CSIC).
  7. Title: Gut microbiota and dietary changes in the adult to elder transition
    Authors: Nuria Salazar 1,2, Silvia Arboleya 1,2, Tania Fernández-Navarro 2,3, Clara G. de los Reyes-Gavilán 1,2, Sonia Gonzalez 2,3, Miguel Gueimonde 1,2
    Affiliations: 1Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Spain. 2Diet, Microbiota and Health Group. Health Research Institute of Principality of Asturias (ISPA), Oviedo, Spain. 3Department of Functional Biology. University of Oviedo. Oviedo, Spain
  8. Title: Effect of n-6 polyunsaturated fatty acid supplementation on clinical course, fatty acid metabolism, pro- and anti- inflammatory cytokines in multiple sclerosis.
    Authors: Laurence S. Harbige1, Mohammad K. Sharief2, Pint E3, Kebreab Ghebremeskel1
    Affiliations: 1Lipidomics and Nutrition Research Centre, London Metropolitan University, United Kingdom. 2Department of Neurology, Colchester General Hospital, Essex, United Kingdom, 3School of Science, Medway Campus, University of Greenwich, United Kingdom
  9. Title: Role of human milk on health and disease of offspring
    Authors: MC Collado
    Affiliation: Institute of Food Science, Technology and Biotechnology (IATA). Spanish National Research Council (CSIC).
  10. Title: Antimicrobial effects and immunomodulatory properties of essential oils: a systematic review
    Authors: Valdivieso-Ugarte M, Gomez-Llorente C, Plaza-Diaz J, Gil A
    Affiliation: Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain; Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, 18016 Armilla, Granada, Spain;  Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain; CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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