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Effect of Terpenoids and Phenolic Compounds in Human Health

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Dear Colleagues,

It is our pleasure to announce a Special Issue titled "Effect of Terpenoids and Phenolic Compounds in Human Health" to be published the journal Nutrients. This Special Issue aims to provide a platform to explore and discuss the effects of medicinal plants on human health, including studies on crude extracts, enriched fractions and isolated bioactive compounds obtained from different plant parts. Particular interest is given to their potential nutraceutical and therapeutic applications, as well as the scientific evidence supporting their biological activity and mechanisms of action.
We welcome the submission of original research articles and review papers. Topics of interest include, but are not limited to:

Molecular mechanisms and signaling pathways underlying the health effects of plant extracts or phytochemicals
The role of plant extracts, fractions, or isolated compounds in the prevention or management of human diseases
Additive, synergistic, or antagonistic effects of combined plant extracts or phytochemicals
Influence of processing, extraction and formulation methods on the bioavailability and biological activity of plant-derived compounds
Applications of plant extracts or phytochemicals in functional foods, dietary supplements and nutraceutical products

We encourage submissions employing diverse methodological approaches, including in vitro, ex vivo, in vivo, in situ, in silico studies, clinical trials, systematic reviews and meta-analyses, to provide comprehensive insights into the health effects of plant-derived products.

We look forward to receiving your valuable contributions and to advancing scientific knowledge in this important and rapidly growing field.

Prof. Dr. Fátima Regina Mena Barreto Silva
Prof. Dr. Diana Marcela Aragon Novoa
Guest Editors

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25 pages, 7982 KB

Open AccessArticle

Mechanistic Biological Insights into the Effects of Resveratrol and Nano-Resveratrol on EAT-Induced Hepatorenal Damage

by Nada Oršolić, Snježana Ramić, Ivana Turk and Daniela Ančić

Nutrients 2026, 18(15), 2444; https://doi.org/10.3390/nu18152444 - 27 Jul 2026

Abstract

Background/Objectives: Malignant ascites is characterized by extensive tumor dissemination within the peritoneal cavity, abnormal fluid accumulation, and progressive multiorgan dysfunction, including hepatic and renal impairment. Methods: The present study was conducted to evaluate the protective effects of resveratrol (RSV) and its nanocrystal formulation (NANO-RSV) at doses of 25 and 50 mg/kg against Ehrlich ascites tumor (EAT)-induced hepatic and renal injury by assessing proliferating cell nuclear antigen (PCNA) expression and apoptosis/necrosis rates, which are key indicators of tissue injury, repair, and regeneration. In addition, microvessel density (MVD) was evaluated in peritoneal tumor tissue, liver, and kidneys to assess angiogenesis and tissue remodeling, while macrophage polarization in the spleen was examined to determine the immunomodulatory effects of RSV and NANO-RSV. Results: Resveratrol and its nano formulations acted as potent inhibitors of EAT cells growth through downregulation of PCNA expression, leading to increased tumor cell death via apoptosis and secondary necrosis. In EAT-bearing mice, the hypoxic microenvironment was associated with increased PCNA expression, enhanced angiogenesis, and reduced apoptosis in hepatic tissue. In contrast, treatment with resveratrol and nano-resveratrol reduced PCNA expression, increased apoptotic activity, suppressed angiogenesis, and induced hepatic steatosis. Progression of steatosis, particularly in resveratrol-treated animals, was associated with impaired hepatic regenerative capacity. In the kidneys, elevated PCNA expression and increased cell death indicated active tissue injury accompanied by compensatory proliferative responses. Furthermore, increased splenic arginase-1 activity correlated with enhanced tissue damage and activation of M2 macrophage-mediated repair mechanisms. Conclusions: In conclusion, resveratrol exhibits significant antitumor activity but may induce organ toxicity, whereas its nanocrystals formulation demonstrates improved safety while maintaining efficacy. Enhanced stability, bioavailability, and sustained-release properties of nano-resveratrol contribute to reduced hepatic and renal injury compared with native resveratrol. Full article

(This article belongs to the Special Issue Effect of Terpenoids and Phenolic Compounds in Human Health)

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