Diet, Lipid and Lipoprotein Metabolism and Human Health

Dear Colleagues,

The strength of evidence for the relationship between diet and cardiovascular disease (CVD) relies heavily on the effects of dietary fat and carbohydrates on serum biomarkers of CVD risk. Serum cholesterol, triglyceride, and critically the concentration and composition of circulating serum lipoproteins that transport these lipids, are prime examples of such serum biomarkers. Serum lipoproteins are causally related to the formation and regression of atherosclerotic lesions in arteries, are highly responsive to changes in diet and food intake, and have major clinical utility in describing the impact of diet on CVD risk. Despite current debate over the role of saturated fat and CVD, the totality of evidence indicates that both serum LDL cholesterol and CVD mortality can be reduced by replacing saturated fatty acids with polyunsaturated fatty acids. On the other hand, a major priority in the dietary management of cardio-metabolic risk arising from insulin resistance and excess visceral and ectopic fat, is not to lower serum LDL cholesterol, but to reduce the atherogencity of lipoprotein remnants, small, dense LDL and dysfunctional HDL. Increasing the intake of dietary long chain n-3 polyunsaturated fatty acids and fibre, at the expense of reducing free sugars, are two ways in which the quality of dietary fat and carbohydrate can be altered to achieve this aim.

This Special Issue welcomes original research and reviews of literature concerning serum lipids, lipoproteins and health under the following topics:

• Human dietary intervention studies that provide evidence for the effects of dietary fatty acids and/or carbohydrates on serum lipids and lipoproteins
• Studies of human genotypes and/or metabolic phenotypes to help explain variation in lipid and lipoprotein responses to dietary macronutrients
• Studies that provide mechanistic insights into the inter-relationship between diet, body composition and serum lipids and lipoproteins and CVD risk
• Effects of dietary patterns and/or specific food groups on serum lipids and lipoproteins

Prof. Bruce A. Griffin
Prof. Julie A. Lovegrove
Guest Editors

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