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Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, B-1200 Brussels, Belgium
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Nutrients 2018, 10(5), 532; https://doi.org/10.3390/nu10050532
Received: 15 March 2018 / Revised: 20 April 2018 / Accepted: 23 April 2018 / Published: 25 April 2018
(This article belongs to the Special Issue Diet, Lipid and Lipoprotein Metabolism and Human Health)
Postprandial hyperlipidemia is an important risk factor for cardiovascular diseases in the context of obesity. Inulin is a non-digestible carbohydrate, known for its beneficial properties in metabolic disorders. We investigated the impact of inulin on postprandial hypertriglyceridemia and on lipid metabolism in a mouse model of diet-induced obesity. Mice received a control or a western diet for 4 weeks and were further supplemented or not with inulin for 2 weeks (0.2 g/day per mouse). We performed a lipid tolerance test, measured mRNA expression of genes involved in postprandial lipid metabolism, assessed post-heparin plasma and muscle lipoprotein lipase activity and measured lipid accumulation in the enterocytes and fecal lipid excretion. Inulin supplementation in western diet-fed mice decreases postprandial serum triglycerides concentration, decreases the mRNA expression levels of Cd36 (fatty acid receptor involved in lipid uptake and sensing) and apolipoprotein C3 (Apoc3, inhibitor of lipoprotein lipase) in the jejunum and increases fecal lipid excretion. In conclusion, inulin improves postprandial hypertriglyceridemia by targeting intestinal lipid metabolism. This work confirms the interest of using inulin supplementation in the management of dyslipidemia linked to obesity and cardiometabolic risk. View Full-Text
Keywords: inulin; postprandial hypertriglyceridemia; obesity inulin; postprandial hypertriglyceridemia; obesity
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Hiel, S.; Neyrinck, A.M.; Rodriguez, J.; Pachikian, B.D.; Bouzin, C.; Thissen, J.-P.; Cani, P.D.; Bindels, L.B.; Delzenne, N.M. Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine. Nutrients 2018, 10, 532.

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