Special Issue "Nutrition, Diet and Celiac Disease"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (1 August 2019).
Interests: Celiac Disease, Probiotics
Special Issues and Collections in MDPI journals
Special Issue in Nutrients: The Expanding World of Prebiotics and Probiotics: Enter the Post-Biotics
Interests: celiac disease; autoimmunity; type-1 diabetes; mucosal immunology
Currently affecting more than one percent of the general population, celiac disease represents an important public health burden, particularly in western countries. It is a systemic autoimmune disorder caused by a pro-inflammatory response arising in the small intestinal mucosa in response to the ingestion of dietary gluten and occurs only in genetically susceptible individuals, carrying the predisposing HLA-DQ2 and/or -DQ8 alleles.
As several other autoimmune disorders, a significant rise in the prevalence of celiac disease has been observed worldwide in the past few decades, due to a combination of improved diagnostic accuracy, increased awareness as well as a higher incidence of new disease cases. This relatively rapid breakout cannot be explained by genetic changes, that require longer times to take place, nor by a change in gluten consumption, that has been shown not to play a major role. On the contrary, environmental triggers have been advanced to contribute to disease onset in genetically susceptible individuals. Gluten is the most important and well-studied among environmental contributors of celiac disease, being required for its development and its removal from the diet representing the only currently accepted and efficient treatment. In addition to gluten, early feeding practices and other dietary factors have been investigated as potential contributors of celiac disease development. Finally, viral infections as well as the composition of small intestinal commensal microbiota have been shown to play a role in disease onset.
In this special issue we aim at clarifying, based on the evidences present in the literature as well as some of the most recent personal findings, what is the role of dietary as well as other environmental factors in celiac disease development.
On another hand, we aim at providing an overview of the pros and cons of the gluten-free diet for celiac disease patients with respect to both short and long-term clinical outcomes, disease complications and prevention of associated pathological conditions. Notably, we will try to approach the gluten-free diet associated issues from multiple prospective including those of physicians, scientists, dietitians and health care providers who daily deal with patients affected by celiac disease
We deeply believe that this multidisciplinary approach, together with the prestige of the selected authors will contribute to an interesting special issue that the reader of Nutrients will value and enjoy.
Prof. Stefano Guandalini
Dr. Valentina Discepolo
Manuscript Submission Information
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- Celiac disease
- Gluten-free diet
- Potential Celiac Disease
- Refractory Celiac disease
- Non-celiac gluten-sensitivity
- Viral infections