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Open AccessReview

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

1
Laboratorio de investigación en Genética de enfermedades complejas, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain
2
Laboratorio de Biología Vascular y Microbiota, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1950; https://doi.org/10.3390/nu11081950
Received: 18 July 2019 / Revised: 13 August 2019 / Accepted: 15 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Nutrition, Diet and Celiac Disease)
We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%–1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women. View Full-Text
Keywords: coeliac disease; reproductive disorders; infertility; recurrent abortion coeliac disease; reproductive disorders; infertility; recurrent abortion
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MDPI and ACS Style

Castaño, M.; Gómez-Gordo, R.; Cuevas, D.; Núñez, C. Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility. Nutrients 2019, 11, 1950. https://doi.org/10.3390/nu11081950

AMA Style

Castaño M, Gómez-Gordo R, Cuevas D, Núñez C. Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility. Nutrients. 2019; 11(8):1950. https://doi.org/10.3390/nu11081950

Chicago/Turabian Style

Castaño, Mercedes; Gómez-Gordo, Rubén; Cuevas, David; Núñez, Concepción. 2019. "Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility" Nutrients 11, no. 8: 1950. https://doi.org/10.3390/nu11081950

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