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Insights and Innovation for Colorectal Cancer Management: Diet and Nutrition Factors

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (15 December 2025) | Viewed by 2359

Editors


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Guest Editor
Department of Family, Youth and Community Sciences, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA
Interests: community-based health promotion; tailored behavior change interventions; health information technologies; cancer prevention and risk reduction; nutritional intervention; nutrition; health behavior; chronic disease prevention; food choice

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Guest Editor
Department of Biobehavioral Nursing Science, College of Nursing, University of Florida, Gainesville, FL, USA
Interests: interventions with use of complementary and integrative medicines (CIM) modalities to improve nutritional status; cancer-cachexia and symptom management in adult patients with gastrointestinal cancers; herbal supplement use to manage symptoms and health promotion in older adults with chronic conditions; nutritional impact on cancr-relatd survivalship; palliative care related to cancer-cachexia in patients with GI cancers
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy
Interests: genetic and epigenetic aberrations in colorectal carcinoma; MAP infection in IBD and IBS in humans; ultrasonography in Crohn’s disease stadiation; microbiota manipulation in IBD
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

This Special Issue, titled "Insights and Innovation for Colorectal Cancer Management: Diet and Nutrition Factors", aims to bring together cutting-edge research exploring colorectal cancer prevention, risk reduction, and survival, with a particular focus on how specific individual and community contexts influence cancer management behaviors and outcomes, including the role of dietary guidelines and several modifiable cancer-related behaviors.

We accept articles covering a variety of topics relevant to colorectal cancer management such as nutritional aspects, social factors, or a combination of both. Specific topics include diverse cancer control guidelines, such as dietary patterns, levels of physical activity or obesity, perspectives and insights into individual behaviors and the built environment, implications of health information, perceptions of prevention behaviors, and social or environmental factors that influence access to resources for colorectal cancer prevention, management, and support, including the value of immunonutrition in patients undergoing surgery or in support of cancer therapies.

As for research methods, we are particularly interested in mixed methods, novel study designs, community-based participatory approaches, and innovative interventions using web-based or digital platforms.

This Special Issue aims to embrace a broad range of perspectives and methodologies, address unique populations and contexts, and provide a deeper understanding of colorectal cancer prevention, management, and survivorship.

Dr. Melissa J. Vilaro
Dr. Saunjoo L. Yoon
Prof. Dr. Antonio Mario Scanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • community-engaged methods
  • web-based interventions
  • nutrition and dietary patterns
  • behavior and lifestyle change
  • personalized nutrition for colorectal cancer
  • symptom management
  • cancer prevention and risk reduction

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Published Papers (1 paper)

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Research

24 pages, 1040 KB  
Article
Gut Microbiota and Nutritional Profiles of Colon Cancer Patients Undergoing Chemotherapy: A Longitudinal Pilot Study
by Claire Han, Daniel Spakowicz, Diane Von Ah, Anne Noonan and Leah Pyter
Nutrients 2026, 18(3), 438; https://doi.org/10.3390/nu18030438 - 29 Jan 2026
Cited by 2 | Viewed by 1684
Abstract
Background/Objectives: Nutrition and the gut microbiota influence treatment tolerance and recovery in patients with colon cancer receiving chemotherapy. This pilot study examined changes in diet quality and fecal microbiota over 6 months of chemotherapy and evaluated longitudinal associations between diet quality and [...] Read more.
Background/Objectives: Nutrition and the gut microbiota influence treatment tolerance and recovery in patients with colon cancer receiving chemotherapy. This pilot study examined changes in diet quality and fecal microbiota over 6 months of chemotherapy and evaluated longitudinal associations between diet quality and gut microbiota diversity and taxa. Methods: 48 adults with stage II–III colon cancer receiving 5-fluorouracil-based chemotherapy were assessed at baseline and 6 months post-initiation. Diet quality was measured using 3-day dietary recalls to calculate Healthy Eating Index (HEI) scores. Stool samples underwent 16S rRNA sequencing to assess Shannon diversity, Beta and taxonomic composition. Pre–post changes were analyzed using paired tests, and associations between HEI and microbiota measures were evaluated using multivariable linear regression adjusting for demographic and clinical covariates. Results: Diet quality declined during chemotherapy, with reduced intake of fiber, fruits and vegetables, and whole grains. Gut microbial alpha diversity decreased over time. At the phylum level, Actinobacteriota decreased, while Bacteroidota and Proteobacteria increased. At the genus level, only Streptococcus (decreased) and Escherichia (increased) remained significantly altered after multiple testing correction. Higher baseline diet quality and improvements over time were associated with greater microbial diversity and lower Proteobacteria abundance. Diet quality was inversely associated with Streptococcus and Escherichia and positively associated with short-chain fatty acid-producing, fiber-responsive genera (Faecalibacterium, Mediterraneibacter, Ruminococcus_E, Fusicatenibacter). Baseline gut microbiota did not significantly associate with changes in diet quality. Conclusions: Chemotherapy was associated with declines in diet quality, gut microbial alpha diversity, along with shifts in beta diversity and microbial taxa. Higher diet quality appeared protective against microbial disruption, supporting a bidirectional relationship between diet and the gut microbiome during chemotherapy. Nutritional and microbiota-focused approaches warrant further investigation in the context of chemotherapy. Full article
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