Advances in Prevention and Management of Celiac Disease

Dear Colleagues,

Celiac disease (CD) is an autoimmune condition characterized by a heterogeneous clinical presentation, affecting any organ or tissue with gastrointestinal and extraintestinal manifestations. CD remains a challenging condition because of a steady increase in its prevalence and comorbidities and the recognition that diagnosis is suboptimal.

We have witnessed an epidemic of CD, questioning the previous paradigm that gluten is the only key element dictating the onset of the CD. A genetic background is a mandatory determinant of the development of the CD, but it is modulated by a diverse range of environmental factors. These include quantity and type of gluten consumption, gut microbiota, diet and lifestyle, exposure to pathogens, loss of intestinal barrier function, inappropriate adaptive immune response, among others. It is of pivotal importance to improve the understanding of factors involving pathophysiology, diagnosis, management, and possible therapeutic options.

In this Special Issue, we would like to introduce readers to the state of the art in the field by presenting papers covering different aspects of environmental factors to identify possible targets for the prevention and management of CD. Both original research articles and reviews spanning clinical and preclinical work are welcome.

Dr. Maria Teresa Nestares Pleguezuelo
Dr. Rafael Martín-Masot
Guest Editors

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