Special Issue "Non-Cytotoxic Nanoparticles"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 28 December 2019

Special Issue Editor

Guest Editor
Prof. Dr. Raphaël Schneider

Laboratoire Réactions et Génie des Procédés, Université de Lorraine, CNRS Address: 1, rue Grandville, BP 20451, 54001 Nancy, France
Website | E-Mail
Phone: +33 3 72 74 37 90
Interests: nanoparticles; fluorescence; bio-imaging; sensing; catalysis; photocatalysis

Special Issue Information

Dear Colleagues,

With the emergence of engineered nanoparticles in a broad range of applications and in several consumer products, toxicological studies have demonstrated that these materials may exhibit complex cytotoxicity depending, among other reasons, on their chemical composition, surface charge states, size and shape, and physicochemical stability.

This Special Issue intends to focus on recently-engineered nanoparticles including semiconductor nanocrystals, iron oxide, graphene, carbon, gold, silver, silica, dendrimers, polymers, etc., exhibiting low toxicity. Synthetic processes, surface modifications, coatings, etc., developed to optimize the design of nanoparticles in view of decreasing their toxicity to biological systems are also of interest.

Prof. Raphaël Schneider
Guest Editor

Manuscript Submission Information

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Keywords

  • nanomaterials
  • nanoparticles
  • non-cytotoxic
  • synthesis optimization
  • surface modification
  • coating

Published Papers (2 papers)

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Research

Open AccessArticle A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita
Nanomaterials 2019, 9(2), 309; https://doi.org/10.3390/nano9020309
Received: 20 January 2019 / Revised: 9 February 2019 / Accepted: 14 February 2019 / Published: 25 February 2019
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Abstract
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co3O4NPs, 60 ± [...] Read more.
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co3O4NPs, 60 ± 6 nm), and chromium oxide (Cr3O4NPs, 50 ± 5 nm)—on freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co3O4NPs was discerned while a low survival rate in the case of Cr3O4NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr3O4NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co3O4NP-, and Cr3O4NP-treated groups. An upgrading in albumin level was witnessed in Co3O4NP- and Cr3O4NP-treated groups while a high level of globulin was noted in NiNP- and Co3O4NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed. Full article
(This article belongs to the Special Issue Non-Cytotoxic Nanoparticles)
Figures

Figure 1

Open AccessArticle Preparation of Messenger RNA Nanomicelles via Non-Cytotoxic PEG-Polyamine Nanocomplex for Intracerebroventicular Delivery: A Proof-of-Concept Study in Mouse Models
Nanomaterials 2019, 9(1), 67; https://doi.org/10.3390/nano9010067
Received: 10 December 2018 / Revised: 30 December 2018 / Accepted: 2 January 2019 / Published: 5 January 2019
PDF Full-text (3273 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The specific delivery of messenger RNA (mRNA) is an excellent alternative to plasmid DNA, due to the latter’s potential risk for random integration into the host genome. In this study, we propose the use of specially tailored polyplex nanomicelles for the intravenous delivery [...] Read more.
The specific delivery of messenger RNA (mRNA) is an excellent alternative to plasmid DNA, due to the latter’s potential risk for random integration into the host genome. In this study, we propose the use of specially tailored polyplex nanomicelles for the intravenous delivery of mRNA into the brain of mice. In brief, along the backbone of a polyaspartamide polymer that is terminated with a 42k Polyethylene glycol chain (PEG), aminoethylene-repeating groups (two, three, and four units, respectively) were conjugated to side-chains to promote electrostatic interactions with mRNA. This structural configuration would ultimately condense into a polyplex nanomicelle ranging between 24 and 34 nm, as was confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS) while the chemistry of the synthesis was validated through NMR analysis. Subsequently, we hypothesized an important correlation pertaining to the role of hydrogen bonding between the interaction of polyamine and mRNA in due course. As a proof of concept, we encapsulated the luciferase (Luc2) mRNA as a reporter gene through in vitro transcription (IVT) and subsequently infused the polyplex nanomicelles into mouse brains via an intracerebroventricular (ICV) injection to bypass the blood–brain barriers (BBB). Data revealed that PEGylated polyplex nanomicelles possessing four repeating units of aminoethylene groups had exhibited the best Luc2 mRNA delivery efficiency with no significant immune response registered. Full article
(This article belongs to the Special Issue Non-Cytotoxic Nanoparticles)
Figures

Graphical abstract

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