Next Article in Journal
Graphene Oxide/Ferrocene-Containing Polymer/Gold Nanoparticle Triple Nanocomposite
Previous Article in Journal
Enhanced and Tunable Electrorheological Capability using Surface Initiated Atom Transfer Radical Polymerization Modification with Simultaneous Reduction of the Graphene Oxide by Silyl-Based Polymer Grafting
Previous Article in Special Issue
Preparation of Messenger RNA Nanomicelles via Non-Cytotoxic PEG-Polyamine Nanocomplex for Intracerebroventicular Delivery: A Proof-of-Concept Study in Mouse Models
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Nanomaterials 2019, 9(2), 309;

A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita

Department of Zoology, Faculty of Natural Science, Lahore College for Women University, Jail Road Lahore 54000, Pakistan
Centre of Excellence in Solid State Physics, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
Author to whom correspondence should be addressed.
Received: 20 January 2019 / Revised: 9 February 2019 / Accepted: 14 February 2019 / Published: 25 February 2019
(This article belongs to the Special Issue Non-Cytotoxic Nanoparticles)
PDF [6445 KB, uploaded 25 February 2019]


In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co3O4NPs, 60 ± 6 nm), and chromium oxide (Cr3O4NPs, 50 ± 5 nm)—on freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co3O4NPs was discerned while a low survival rate in the case of Cr3O4NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr3O4NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co3O4NP-, and Cr3O4NP-treated groups. An upgrading in albumin level was witnessed in Co3O4NP- and Cr3O4NP-treated groups while a high level of globulin was noted in NiNP- and Co3O4NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed. View Full-Text
Keywords: nanoparticles; nanotoxicity; Labeo rohita; sub-chronic exposure; biomolecules nanoparticles; nanotoxicity; Labeo rohita; sub-chronic exposure; biomolecules

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kanwal, Z.; Raza, M.A.; Manzoor, F.; Riaz, S.; Jabeen, G.; Fatima, S.; Naseem, S. A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita. Nanomaterials 2019, 9, 309.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top