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Nanomaterials
Volume 9
Issue 2
10.3390/nano9020309
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Article

A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita

by
Zakia Kanwal
1,
Muhammad Akram Raza
2,*,
Farkhanda Manzoor
1,
Saira Riaz
2,
Ghazala Jabeen
1,
Shafaq Fatima
1 and
Shahzad Naseem
2
1
Department of Zoology, Faculty of Natural Science, Lahore College for Women University, Jail Road Lahore 54000, Pakistan
2
Centre of Excellence in Solid State Physics, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 309; https://doi.org/10.3390/nano9020309
Submission received: 20 January 2019 / Revised: 9 February 2019 / Accepted: 14 February 2019 / Published: 25 February 2019
(This article belongs to the Special Issue Non-cytotoxic Nanoparticles)
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Abstract

In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co3O4NPs, 60 ± 6 nm), and chromium oxide (Cr3O4NPs, 50 ± 5 nm)—on freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co3O4NPs was discerned while a low survival rate in the case of Cr3O4NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr3O4NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co3O4NP-, and Cr3O4NP-treated groups. An upgrading in albumin level was witnessed in Co3O4NP- and Cr3O4NP-treated groups while a high level of globulin was noted in NiNP- and Co3O4NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed.
Keywords: nanoparticles; nanotoxicity; Labeo rohita; sub-chronic exposure; biomolecules nanoparticles; nanotoxicity; Labeo rohita; sub-chronic exposure; biomolecules

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MDPI and ACS Style

Kanwal, Z.; Raza, M.A.; Manzoor, F.; Riaz, S.; Jabeen, G.; Fatima, S.; Naseem, S. A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita. Nanomaterials 2019, 9, 309. https://doi.org/10.3390/nano9020309

AMA Style

Kanwal Z, Raza MA, Manzoor F, Riaz S, Jabeen G, Fatima S, Naseem S. A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita. Nanomaterials. 2019; 9(2):309. https://doi.org/10.3390/nano9020309

Chicago/Turabian Style

Kanwal, Zakia, Muhammad Akram Raza, Farkhanda Manzoor, Saira Riaz, Ghazala Jabeen, Shafaq Fatima, and Shahzad Naseem. 2019. "A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita" Nanomaterials 9, no. 2: 309. https://doi.org/10.3390/nano9020309

APA Style

Kanwal, Z., Raza, M. A., Manzoor, F., Riaz, S., Jabeen, G., Fatima, S., & Naseem, S. (2019). A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita. Nanomaterials, 9(2), 309. https://doi.org/10.3390/nano9020309

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