Mass Spectrometry Imaging
A special issue of Methods and Protocols (ISSN 2409-9279).
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 6544
Special Issue Editor
2. National Human Reproduction Laboratory, University of Pécs, 7624 Pécs, Hungary
3. ELKH-PTE Human Reproduction Research Group, University of Pécs, 7624 Pécs, Hungary
Interests: mass spectrometry; imaging mass spectrometry; embryogenesis; cancer diagnosis; andrology; fertilization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mass spectrometry imaging (MSI) makes the possibility of combining histological information with a label-free mass spectrometric imaging technology. MSI has emerged as an important tool to visualize the spatial distributions of even hundreds of biomolecules, directly from the sample surface. Various ionization techniques have been implemented for molecular imaging of biological tissue sections. Secondary ion mass spectrometry (SIMS) and matrix assisted laser desorption ionization (MALDI) mass spectrometry are the most widely-used MSI methods, both of which require vacuum conditions. Ambient ionization MSI techniques have grown rapidly in the past decade as well, enabling the analysis under atmospheric pressure with minimum or no sample preparation. In vivo and in situ MSI have become approachable with the advent of ambient ionization sources, such as laser ablation electrospray ionization (LAESI), desorption electrospray ionization (DESI), desorption atmospheric pressure photoionization (DAPPI), probe electrospray ionization (PESI), nanospray desorption electrospray ionization (nanoDESI), etc. MSI facilitates the simultaneous imaging of small metabolites, lipids, polypeptides, and large proteins in tissue sections. Soft ionization yields minimum fragmentation attributing to its relative low energy deposition and thus keeps the biomolecules intact. MSI has been extensively applied in different fields including pharmaceutical drug development, biochemistry, forensic science, clinical research, and biomarker discovery.
In this Special Issue on “Mass Spectrometry Imaging”, we welcome researchers to submit both original research manuscripts, as well as review papers, on all areas of in vitro and in vivo Imaging Mass Spectrometry. The goal of this Special Issue is to collect the most recent state of the art technological developments, applications, sample pre-treatment protocols and data analysis workflows in this emerging scientific field.
Dr. Laszlo Mark
Guest Editor
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Keywords
- imaging
- mass spectrometry
- MALDI
- SIMS
- LAESI
- DESI
- tissue section
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