Special Issue "Phytoalexins: Current Progress and Future Prospects"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 30 April 2014

Special Issue Editor

Guest Editor
Prof. Dr. Philippe Jeandet
Laboratory of Stress, Defenses and Plant Reproduction, U.R.V.V.C., UPRES EA 4707, Faculty of Sciences, University of Reims, PO Box. 1039, 51687 Reims cedex 02, France
Website: http://www.mdpi.com/files/misc/cv-prof-dr-philippe-jeandet.pdf
E-Mail: philippe.jeandet@univ-reims.fr
Phone: +33 3 26 91 33 41
Interests: plant defense mechanisms; particularly study of the grapevine (Vitis spp.) phytoalexins (resveratrol and derivatives): chemical synthesis; biosynthesis; chemical analyses; phytoalexin metabolism by Botrytis cinerea; antifungal activity and molecular engineering of resveratrol in plants and microbial cells

Special Issue Information

Dear Colleagues,

Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. It is now clear that phytoalexins exhibit toxicity across much of the biological spectrum, prokaryotic and eukaryotic. Starting in the 1950s, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their structure, their biological activity as well as mechanisms of their synthesis and their catabolism by microorganisms. Elucidation of the biosynthesis of numerous phytoalexins has also permitted the use of molecular biology tools for the exploration of the genes encoding enzymes of their synthesis pathways and their regulators. This has led to potential applications for increasing plant resistance to diseases. Phytoalexins display an enormous diversity belonging to various chemical families such as isoflavones, isoflavanones, pterocarpans, isoflavans, flavanones, coumestans, furanoacetylenes, phenylpropanoids, steroid glycoalkaloids, norsesquiterpenoids/sesquiterpenoids, coumarins, diterpenes, ent-kaurane-related diterpenoids, acidic sesquiterpenoids, 3-deoxyanthocyanidins, naphthaldehydes, indoles and stilbenes.
Research papers dealing with all aspects of phytoalexins, including structure elucidation; chemical synthesis; methods for phytoalexin analysis in plant extracts or biological fluids; biosynthesis studies including modulation of phytoalexin synthesis; engineering of phytoalexin biochemical pathways in plants and microbes; biological activities; structure/activity relationships; phytoalexin metabolism in planta and by micro-organisms; roles and ATP Binding Cassette (ABC) transporters or Multi-Drugs Efflux (MDE) transporters are welcome for inclusion in this Special Issue of Molecules. Review articles, particularly those dealing with the themes mentioned above are also particularly welcome for inclusion.

Prof. Dr. Philippe Jeandet
Guest Editor


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  • phytoalexin structure elucidation
  • chemical synthesis
  • methods for phytoalexin analysis
  • biosynthetic studies and modulation of phytoalexin biosynthesis
  • molecular engineering in plants and microbes / applications
  • biological activities
  • structure/activity relationships
  • plant metabolism
  • fungal metabolism
  • transport mechanisms
  • applications

Published Papers (2 papers)

Molecules 2014, 19(4), 3988-4005; doi:10.3390/molecules19043988
Received: 7 January 2014; in revised form: 5 March 2014 / Accepted: 5 March 2014 / Published: 2 April 2014
Show/Hide Abstract | Download PDF Full-text (2117 KB) | Download XML Full-text

Molecules 2014, 19(2), 1432-1458; doi:10.3390/molecules19021432
Received: 10 December 2013; in revised form: 2 January 2014 / Accepted: 13 January 2014 / Published: 27 January 2014
Show/Hide Abstract | Download PDF Full-text (541 KB) | View HTML Full-text | Download XML Full-text

Last update: 29 August 2013

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