Special Issue "Bioactive Natural Peptides As A Pipeline For Therapeutics"
Deadline for manuscript submissions: closed (30 September 2017)
Dr. Philippe Bulet
1. University Grenoble Alpes, Institute for Advanced Biosciences, Inserm 1209, CNRS UMR5309, Equipe Immunologie Analytique des Pathologies Chroniques, F-38000 Grenoble, France
2. Plateforme BioPark d'Archamps, Bât. Le Forum 1, 260 Avenue Marie Curie, Archamps Technopole, F-74166 Saint Julien en Genevois Cedex, France
Website | E-Mail
Phone: +33 4 50 43 25 21
Interests: biochemistry; inflammation; innate immunity
Biodiversity is an extraordinarily ingenious provider of diverse natural products, among which bioactive natural peptides are important contributors.
Bioactive natural peptides are ubiquitous in all living organisms. They have been reported in marine and terrestrial organisms, including plants and are targeting vital physiological processes. In addition, to maintain homeostasis of the host, bioactive natural peptides are mediating a number of physiological responses that lead to protection of the organism against attacks (i.e., innate immunity, venom). Our knowledge of bioactive natural peptides has been largely enriched thanks to the peptides originated from venoms and from the armamentarium, developed by the living organisms to fight off infections through the innate immune defenses. As bioactive peptides obtained from nature have been subjected to eons of selective pressure, they show several advantages over in silico designed peptide-like compounds. The extensive investigations of the different sources of bioactive natural peptides (i.e., defense peptides, toxins) have identified thousands of structures, adopting different conformations. For example, they can exhibit α-helical conformations, amphipathic β-hairpin-like β-sheet, β-sheet, α-helix/β-sheet mixed folds up or multi fingers folds. Interestingly, structural analyses between toxins and defense peptides revealed important interrelations between these two groups of bioactive peptides (toxic versus antimicrobial). Genomic analyses suggest that these bioactive molecules share a common ancestor. Bioactive natural peptides can exert highly specific activities, or, in contrast, have multifunctional properties. Therefore, it is not surprising that research has focused on identifying bioactive natural peptides for their development of new therapeutics. Captopril, exenatide and ziconotide, are examples of already marketed therapeutics developed from bioactive peptides isolated from venoms. In the field of antimicrobial peptides, so far magainin has reached the very last stages of the FDA approval. Bioactive natural peptides should definitively continue to fill pharmaceutical and biotechs pipelines, in the ongoing global search for therapeutic agents in the treatment of human and animal pathologies, and for phytosanitary purposes. This Special Issue will examine the recent progress in the search for bioactive natural peptides lead compounds and their potential therapeutic development; for example, in the field of medicinal application as antitumoral, antimicrobial, anticoagulating, and for analgesic properties.
Dr. Philippe Bulet
Manuscript Submission Information
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- bioactive natural peptides
- molecular diversity
- defense peptides
- therapeutic peptides