Peptide-Based Drugs and Drug Delivery Systems
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 May 2017) | Viewed by 213098
Special Issue Editors
Interests: anti-infective agents; antimicrobial peptides; antiparasitic drugs; drug rescuing and repurposing; peptide-grafted materials; peptide synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Peptides are ubiquitously found as relevant molecular tools in Research and Development, from Molecular Biology to Materials Science, from Synthetic Chemistry to Computational and Structural Biology, from Food Science to Biotechnology, from Early Drug Discovery to the Clinics, from Academia to Industry, etc, in summary, peptides offer no less than a whole world of possibilities to Science and Technology.
Over 150 peptide therapeutics have recently entered clinical trials, a number that remains low, as compared to that of small molecular drug candidates. Still, a paradigm shift in the Pharmaceutical Industry, regarding peptide-based drugs, is under way: until recent years, pharma companies have mostly put their bets on small molecules as drugs, leaving larger peptide-based candidates put aside, on the grounds of their low oral bioavailability and short half-life in vivo, among other limitations; however, small drugs often suffer from reduced selectivity, leading to unwanted off-target side effects, whereas peptides usually display an extraordinary specificity for their targets, which may largely compensate for their low bioavailability, poor permeability and susceptibility to metabolic inactivation. Moreover, chemical methods for peptide synthesis have been gaining efficacy, robustness and capability to produce peptides and peptidomimetics of increasing size and structural complexity, at overall production costs that have been steadily decreasing. Last, but not least, the emergent field of peptide-based materials for biomedical applications, has been gaining prominence.
In connection with the above, the present Special Issue is aimed at covering new approaches, methodologies, and perspectives towards development of peptide-based drugs, materials and drug delivery systems, for biomedical applications.
Prof. Dr. Paula A. C. Gomes
Prof. Dr. Stefania Galdiero
Guest Editors
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Keywords
- antimicrobial Peptides
- antiparasitic peptides
- cell penetrating peptides
- peptides and diabetes
- collagen-stimulating peptides
- peptide-based materials
- peptide therapeutics
- peptides in biomedical engineering
- peptide synthesis
- peptidomimetics
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