Special Issue "Breakthroughs in Antimicrobial Peptides"

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (31 May 2019)

Special Issue Editor

Guest Editor
Prof. Stefania Galdiero

University of Naples Federico II, Department of Pharmacy, Via Mezzocannone 16, 80134 Napoli, Italy
Website 1 | Website 2 | E-Mail
Interests: drug delivery; peptides; active and passive targeting; nanoparticles; antimicrobial peptides

Special Issue Information

Dear Colleagues,

Antimicrobial peptides (AMPs) are continuously attracting attention as a challenging opportunity for advanced medical applications. The rapid worldwide development of resistance to conventional antibiotics makes it imperative to allocate efforts to bring AMPs with advanced properties into clinical use. In fact, antibiotic resistance is a priority concern, and the technological development of new materials with antimicrobial properties provides a breakthrough for the discovery of new molecules for therapeutic use.

This Special Issue of Pharmaceutics focuses on new strategies and approaches to AMP-based systems intended for antimicrobial therapies, which could also be combined with anti-cancer therapies. We welcome articles concerning all aspects of AMP-based molecules designed for advanced therapy. Especially, studies on the relationships between biophysical features and activities, new materials, original synthetic approaches, innovative formulation and delivery strategies are welcome for this Special Issue. Articles illustrating current and future trends in the development of AMP therapeutics spanning a multitude of disciplines including chemistry, physics, biology, pharmaceutical materials science, and contributing to the design of highly active molecules are highly encouraged.

Prof. Stefania Galdiero
Guest Editor

Manuscript Submission Information

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Keywords

  • peptide
  • antimicrobials
  • membranes
  • bacteria
  • biofilm
  • materials

Published Papers (1 paper)

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Review

Open AccessReview
A New Hope: Self-Assembling Peptides with Antimicrobial Activity
Pharmaceutics 2019, 11(4), 166; https://doi.org/10.3390/pharmaceutics11040166
Received: 6 March 2019 / Revised: 22 March 2019 / Accepted: 29 March 2019 / Published: 4 April 2019
PDF Full-text (1094 KB) | HTML Full-text | XML Full-text
Abstract
Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional [...] Read more.
Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described. Full article
(This article belongs to the Special Issue Breakthroughs in Antimicrobial Peptides)
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