Special Issue "Oligosaccharides and Glyco-Conjugates"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 March 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Marco Terreni
Department of Drug Sciences; School of Pharmacy; University of Pavia, Via Taramelli 12; 27100 Pavia, Italy
Website: http://dipsf.unipv.eu/site/home.html
E-Mail: marco.terreni@unipv.it
Interests: syndetic organic chemistry; medicinal chemistry; chemical biology; protein engineering; biocatalysis

Guest Editor
Dr. Caterina Temporini
Department of Drug Sciences; School of Pharmacy; University of Pavia, Via Taramelli 12; 27100 Pavia, Italy
Website: http://dipsf.unipv.eu/site/home.html
E-Mail: caterina.temporini@unipv.it
Interests: analytical chemistry; medicinal chemistry; protein engeenering

Special Issue Information

Dear Colleagues,

Carbohydrates occur naturally as oligo- and polysaccharides and are often coupled to peptides. proteins and lipids. In particular, oligosaccharides and glyco-conjugates have key roles in a broad range of biological processes. In many cases, changes in the sugar structures can affect the biological properties of the parent compounds. Furthermore, functional properties of drugs such as solubility, pharmacokinetics or pharmacodynamics can be enhanced by the incorporation of carbohydrate moieties into the molecules.
Methods for synthesizing these molecules have, therefore, acquired immense importance, because it is not easy to isolate sufficient amounts of acceptable pure product from natural sources.
On the other hand, the structure of therapeutic bio-products is critically important for their efficacy and safety, and the ability to characterize it at various levels (from sequence to conformation) is critical not only at the quality control stage, but also throughout the discovery and design stages because these structural information enable to optimize and enhance their therapeutic profile in a rational fashion.
Many analytical technologies have been deeply improved in the last years for determining the exact structure of complex oligosaccharides and glyco-conjugates For example Liquid Chromatography coupled to mass spectrometry (LC-MS) offers a variety of approaches to study structure and behaviour of complex protein drugs and has already become a default tool for characterizing the covalent structure, including sequence and post-translational modifications such as glycosylation which is the most common PTM in currently developed biopharmaceuticals.
Research papers dealing with the study and development of new compounds as well as new synthetic approaches, including new enzymatic or chemoenzymatic methods, new methods for analytical and biological characterization of oligosaccharides and glyco-conjugates, are welcomed for inclusion into this Special Issue of Molecules. Review articles, particularly those dealing with retrospective analyses of prior successes in the discovery and/or development of new drugs based on oligosaccharides and glyco-conjugates, are also welcomed for inclusion.

Prof. Dr. Marco Terreni
Dr. Caterina Temporini
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • oligosaccharides
  • glycopeptides
  • glycoproteins
  • glycolipids
  • synthesis
  • analysis
  • structure characterization
  • biological activity
  • structure based drug design
  • drug discovery and development

Published Papers (5 papers)

Molecules 2014, 19(4), 5421-5433; doi:10.3390/molecules19045421 (doi registration under processing)
Received: 5 March 2014; in revised form: 18 April 2014 / Accepted: 21 April 2014 / Published: 24 April 2014
Show/Hide Abstract | Download PDF Full-text (1346 KB) |  Supplementary Files

Molecules 2014, 19(4), 4578-4594; doi:10.3390/molecules19044578
Received: 11 February 2014; in revised form: 2 April 2014 / Accepted: 4 April 2014 / Published: 11 April 2014
Show/Hide Abstract | Download PDF Full-text (812 KB)

Molecules 2014, 19(3), 3744-3760; doi:10.3390/molecules19033744
Received: 27 January 2014; in revised form: 28 February 2014 / Accepted: 5 March 2014 / Published: 24 March 2014
Show/Hide Abstract | Download PDF Full-text (2340 KB)
abstract graphic

Molecules 2014, 19(1), 1328-1343; doi:10.3390/molecules19011328
Received: 3 December 2013; in revised form: 13 January 2014 / Accepted: 16 January 2014 / Published: 21 January 2014
Show/Hide Abstract | Download PDF Full-text (2126 KB) | View HTML Full-text | Download XML Full-text

Molecules 2014, 19(1), 414-437; doi:10.3390/molecules19010414
Received: 13 December 2013; in revised form: 24 December 2013 / Accepted: 25 December 2013 / Published: 31 December 2013
Show/Hide Abstract | Download PDF Full-text (402 KB) | View HTML Full-text | Download XML Full-text
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Last update: 20 August 2013

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