Special Issue "Potential Neuromodulatory Profile of Phytocompounds in Brain Disorders"
Deadline for manuscript submissions: closed (30 June 2016).
A printed edition of this Special Issue is available here.
This Special Issue is dedicated to the neuromodulatory effects of phytocompounds in brain pathologies. Nowadays, natural and chemical compounds, derived from plants, algae, vegetables, and fruits, are used as dietary supplements, as well as alternative medicines. Several studies have evidenced that herbal preparations have been used to treat brain disorders because of their chemical properties and abilities to pass the blood brain barriers and by influencing the brain’s neurochemical and functional pathways. In particular, several plants have been reported to treat cognitive, psychiatric and mood disorders, although the mechanisms of these actions remain to be elucidated. In vitro and in vivo studies have demonstrated a key role of medicinal plants in maintaining the brain’s function by influencing the expression of different receptors, signal transduction pathways, transcription factors, and neurotransmitter release. Moreover, neuroinflammation and oxidative stress have been proposed to be crucially involved in central nervous system dysfunctions, and recent investigations are elucidating novel therapeutic targets based on the neuroprotective properties of different phytoderivates. Thus, the aim of the present Special Issue is to highlight the neuromodulatory effects of different natural and chemical phyto-derivates in order to identify novel mechanisms and signaling molecules that, in the future, could provide a potential and promising class of therapeutics for the treatment of psychiatric and neurodegenerative disorders.
Dr. Luigia Trabace
Manuscript Submission Information
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- central nervous system
- psychiatric disorders