Next Article in Journal
Growing and Etching MoS2 on Carbon Nanotube Film for Enhanced Electrochemical Performance
Next Article in Special Issue
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?
Previous Article in Journal
Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A
Previous Article in Special Issue
The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(10), 1311;

Chlorella sorokiniana Extract Improves Short-Term Memory in Rats

Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71121, Italy
Department of Physiology and Pharmacology, “Sapienza” University of Rome, Rome 00185, Italy
STAR Agroenergy Research Group, University of Foggia, Via Gramsci, 89-91, Foggia 71121, Italy
Institute of Marine Science, National Research Council, via Pola 4, Lesina 71010, Italy
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 August 2016 / Revised: 21 September 2016 / Accepted: 23 September 2016 / Published: 29 September 2016
Full-Text   |   PDF [1628 KB, uploaded 29 September 2016]   |  


Increasing evidence shows that eukaryotic microalgae and, in particular, the green microalga Chlorella, can be used as natural sources to obtain a whole variety of compounds, such as omega (ω)-3 and ω-6 polyunsatured fatty acids (PUFAs). Although either beneficial or toxic effects of Chlorella sorokiniana have been mainly attributed to its specific ω-3 and ω-6 PUFAs content, the underlying molecular pathways remain to be elucidated yet. Here, we investigate the effects of an acute oral administration of a lipid extract of Chlorella sorokiniana, containing mainly ω-3 and ω-6 PUFAs, on cognitive, emotional and social behaviour in rats, analysing possible underlying neurochemical alterations. Our results showed improved short-term memory in Chlorella sorokiniana-treated rats compared to controls, without any differences in exploratory performance, locomotor activity, anxiety profile and depressive-like behaviour. On the other hand, while the social behaviour of Chlorella sorokiniana-treated animals was significantly decreased, no effects on aggressivity were observed. Neurochemical investigations showed region-specific effects, consisting in an elevation of noradrenaline (NA) and serotonin (5-HT) content in hippocampus, but not in the prefrontal cortex and striatum. In conclusion, our results point towards a beneficial effect of Chlorella sorokiniana extract on short-term memory, but also highlight the need of caution in the use of this natural supplement due to its possible masked toxic effects. View Full-Text
Keywords: Chlorella sorokiniana; short-term memory; emotional behaviour; serotonin; noradrenaline; hippocampus Chlorella sorokiniana; short-term memory; emotional behaviour; serotonin; noradrenaline; hippocampus

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Morgese, M.G.; Mhillaj, E.; Francavilla, M.; Bove, M.; Morgano, L.; Tucci, P.; Trabace, L.; Schiavone, S. Chlorella sorokiniana Extract Improves Short-Term Memory in Rats. Molecules 2016, 21, 1311.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top