Research

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17 pages, 6890 KiB

Open AccessArticle

Preparation of Gelatin-Quaternary Ammonium Salt Coating on Titanium Surface for Antibacterial/Osteogenic Properties

by Hongyang Song, Lei Xing, Jinjian Wei, Xue Wang, Yaozhen Yang, Pengbo Zhe, Mingming Luan and Jing Xu

Molecules 2023, 28(12), 4570; https://doi.org/10.3390/molecules28124570 - 06 Jun 2023

Cited by 1 | Viewed by 1318

Abstract

Titanium (Ti) and its alloys are widely used in medical treatment, engineering, and other fields because of their excellent properties including biological activity, an elastic modulus similar to that of human bones, and corrosion resistance. However, there are still many defects in the [...] Read more.

Titanium (Ti) and its alloys are widely used in medical treatment, engineering, and other fields because of their excellent properties including biological activity, an elastic modulus similar to that of human bones, and corrosion resistance. However, there are still many defects in the surface properties of Ti in practical applications. For example, the biocompatibility of Ti with bone tissue can be greatly reduced in implants due to a lack of osseointegration as well as antibacterial properties, which may lead to osseointegration failure. To address these problems and to take advantage of the amphoteric polyelectrolyte properties of gelatin, a thin layer of gelatin was prepared by electrostatic self-assembly technology. Diepoxide quaternary ammonium salt (DEQAS) and maleopimaric acid quaternary ammonium salt (MPA−N⁺) were then synthesized and grafted onto the thin layer. The cell adhesion and migration experiments demonstrated that the coating has excellent biocompatibility, and those grafted with MPA−N⁺ promoted cell migration. The bacteriostatic experiment showed that the mixed grafting with two ammonium salts had excellent bacteriostatic performance against Escherichia coli and Staphylococcus aureus, with bacteriostasis rates of 98.1 ± 1.0% and 99.2 ± 0.5%, respectively. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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17 pages, 9255 KiB

Open AccessArticle

Influence of a Composite Polylysine-Polydopamine-Quaternary Ammonium Salt Coating on Titanium on Its Ostogenic and Antibacterial Performance

by Lei Xing, Hongyang Song, Jinjian Wei, Xue Wang, Yaozhen Yang, Pengbo Zhe, Mingming Luan and Jing Xu

Molecules 2023, 28(10), 4120; https://doi.org/10.3390/molecules28104120 - 16 May 2023

Cited by 1 | Viewed by 1219

Abstract

Thin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces [...] Read more.

Thin oxide layers form easily on the surfaces of titanium (Ti) components, with thicknesses of <100 nm. These layers have excellent corrosion resistance and good biocompatibility. Ti is susceptible to bacterial development on its surface when used as an implant material, which reduces the biocompatibility between the implant and the bone tissue, resulting in reduced osseointegration. In the present study, Ti specimens were surface-negatively ionized using a hot alkali activation method, after which polylysine and polydopamine layers were deposited on them using a layer-by-layer self-assembly method, then a quaternary ammonium salt (QAS) (EPTAC, DEQAS, MPA-N⁺) was grafted onto the surface of the coating. In all, 17 such composite coatings were prepared. Against Escherichia coli and Staphylococcus aureus, the bacteriostatic rates of the coated specimens were 97.6 ± 2.0% and 98.4 ± 1.0%, respectively. Thus, this composite coating has the potential to increase the osseointegration and antibacterial performance of implantable Ti devices. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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12 pages, 2208 KiB

Open AccessArticle

Facile Synthesis of Quinolinecarboxylic Acid–Linked Covalent Organic Framework via One–Pot Reaction for Highly Efficient Removal of Water–Soluble Pollutants

by Mingzhu Yang and Wenhua Ji

Molecules 2023, 28(9), 3752; https://doi.org/10.3390/molecules28093752 - 27 Apr 2023

Cited by 1 | Viewed by 1473

Abstract

To efficiently eliminate highly polar organic pollutants from water has always been a difficult issue, especially in the case of ultralow concentrations. Herein, we present the facile synthesis of quinolinecarboxylic acid-linked COF (QCA–COF) via the Doebner multicomponent reaction, possessing multifunction, high specific surface [...] Read more.

To efficiently eliminate highly polar organic pollutants from water has always been a difficult issue, especially in the case of ultralow concentrations. Herein, we present the facile synthesis of quinolinecarboxylic acid-linked COF (QCA–COF) via the Doebner multicomponent reaction, possessing multifunction, high specific surface area, robust physicochemical stability, and excellent crystallinity. The marked feature lies in the quinolinyl and carboxyl functions incorporated simultaneously to QCA–COF in one step. The major cis–orientation of carboxyl arms in QCA–COF was speculated by powder X–ray diffraction and total energy analysis. QCA–COF demonstrates excellent adsorption capacity for water–soluble organic pollutants such as rhodamine B (255.7 mg/g), methylene blue (306.1 mg/g), gentamycin (338.1 mg/g), and 2,4–dichlorophenoxyacetic acid (294.1 mg/g) in water. The kinetic adsorptions fit the pseudo–second order model and their adsorption isotherms are Langmuir model. Remarkably, QCA–COF can capture the above four water–soluble organic pollutants from real water samples at ppb level with higher than 95% removal efficiencies and excellent recycling performance. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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13 pages, 2399 KiB

Open AccessArticle

An Imine-Based Porous 3D Covalent Organic Polymer as a New Sorbent for the Solid-Phase Extraction of Amphenicols from Water Sample

by Jinjian Wei, Lengbing Chen, Rui Zhang, Yi Yu, Wenhua Ji, Zhaosheng Hou, Yuqin Chen and Zhide Zhang

Molecules 2023, 28(8), 3301; https://doi.org/10.3390/molecules28083301 - 07 Apr 2023

Cited by 1 | Viewed by 1363

Abstract

In this paper, an imine-based porous 3D covalent organic polymer (COP) was synthesized via solvothermal condensation. The structure of the 3D COP was fully characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and powder X-ray diffractometry, thermogravimetric analysis, and [...] Read more.

In this paper, an imine-based porous 3D covalent organic polymer (COP) was synthesized via solvothermal condensation. The structure of the 3D COP was fully characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and powder X-ray diffractometry, thermogravimetric analysis, and Brunauer–Emmer–Teller (BET) nitrogen adsorption. This porous 3D COP was used as a new sorbent for the solid-phase extraction (SPE) of amphenicol drugs, including chloramphenicol (CAP), thiamphenicol (TAP), and florfenicol (FF) in aqueous solution. Factors were investigated for their effects on the SPE efficiency, including the types and volume of eluent, washing speed, pH, and salinity of water. Under the optimized conditions, this method gave a wide linear range (0.1–200 ng/mL) with a high correlation coefficient value (R² > 0.99), low limits of detection (LODs, 0.01–0.03 ng/mL), and low limits of quantification (LOQs, 0.04–0.10 ng/mL). The recoveries ranged from 83.98% to 110.7% with RSDs ≤ 7.02%. The good enrichment performance for this porous 3D COP might contribute to the hydrophobic and π–π interactions, the size-matching effect, hydrogen bonding, and the good chemical stability of 3D COP. This 3D COP-SPE method provides a promising approach to selectively extract trace amounts of CAP, TAP, and FF in environmental water samples in ng quantities. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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10 pages, 2609 KiB

Open AccessArticle

Facile Synthesis of Cyclic Polyamidine with High Cationic Degree Using Environmentally Benign Approach

by Bo Guo, Xinghua Teng, Xiaohan Guo, Sen Zhang, Leilei Wang and Jianing Wang

Molecules 2023, 28(6), 2530; https://doi.org/10.3390/molecules28062530 - 10 Mar 2023

Viewed by 844

Abstract

An environmentally benign approach was developed to fabricate cyclic polyamidine via polymerization in supercritical carbon dioxide (SCCO₂) and subsequently amidinization in water. Synthetic parameters were evaluated using response surface methodology. In comparison with aqueous solution polymerization for the fabrication of PNVF-co-PAN, [...] Read more.

An environmentally benign approach was developed to fabricate cyclic polyamidine via polymerization in supercritical carbon dioxide (SCCO₂) and subsequently amidinization in water. Synthetic parameters were evaluated using response surface methodology. In comparison with aqueous solution polymerization for the fabrication of PNVF-co-PAN, polymerization using SCCO₂ is favorable to promote the yield and viscosity of PNVF-co-PAN and diminished reaction time on account of excellent solvation capacity and transport property of SCCO₂. Replacing the traditional water solution with SCCO₂ as a green solvent could heighten the purity of PNVF-co-PAN by virtue of the excellent extraction of SCCO₂. The cationic degree (5.66 mmol/g) of polyamidine fabricated by environmentally benign approach was significantly higher than that in previous reported studies. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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13 pages, 3141 KiB

Open AccessArticle

Enhanced Tensile Properties, Biostability, and Biocompatibility of Siloxane–Cross-Linked Polyurethane Containing Ordered Hard Segments for Durable Implant Application

by Xiaofei Wu, Hanxiao Jia, Wenshuo Fu, Meng Li and Yitong Pan

Molecules 2023, 28(6), 2464; https://doi.org/10.3390/molecules28062464 - 08 Mar 2023

Cited by 2 | Viewed by 1177

Abstract

This work developed a series of siloxane-modified polyurethane (PU–Si) containing ordered hard segments by a facile method. The polyaddition between poly(ε-caprolactone) and excess diurethane diisocyanate was carried out to synthesize a polyurethane prepolymer with terminal isocyanate groups, which was then end-capped by 3-aminopropyl [...] Read more.

This work developed a series of siloxane-modified polyurethane (PU–Si) containing ordered hard segments by a facile method. The polyaddition between poly(ε-caprolactone) and excess diurethane diisocyanate was carried out to synthesize a polyurethane prepolymer with terminal isocyanate groups, which was then end-capped by 3-aminopropyl triethoxysilane to produce alkoxysilane-terminated polyurethane; the target products of PU–Si were obtained with hydrolysis and the condensation of alkoxysilane groups. The chemical structures were confirmed by FT-IR and XPS, and the effect of the siloxane content or cross-linked degree on the physicochemical properties of the PU–Si films was investigated in detail. The formation of the network structure linked by Si–O–Si bonds and interchain denser hydrogen bonds endowed PU–Si films with fine phase compatibility, low crystallinity, high thermal stability, and excellent tensile properties. Due to the high cross-linked degree and low interfacial energy, the films displayed a high surface water contact angle and low equilibrium water absorption, which resulted in slow hydrolytic degradation rates. Furthermore, the evaluation of protein adsorption and platelet adhesion on the PU–Si film surface presented high resistance to biofouling, indicating superior surface biocompatibility. Consequently, the siloxane–cross-linked polyurethane, which possessed excellent tensile properties, high biostability, and superior biocompatibility, showed great potential to be explored as biomaterials for durable implants. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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13 pages, 3857 KiB

Open AccessArticle

Free Linoleic Acid and Oleic Acid Reduce Fat Digestion and Absorption In Vivo as Potent Pancreatic Lipase Inhibitors Derived from Sesame Meal

by Xuan Li, Sayo Morita, Hiroaki Yamada, Keita Koga, Wakana Ota, Toma Furuta, Atsushi Yamatsu and Mujo Kim

Molecules 2022, 27(15), 4910; https://doi.org/10.3390/molecules27154910 - 01 Aug 2022

Cited by 10 | Viewed by 1949

Abstract

Pancreatic lipase catalyzes the cleavage of triacylglycerols at the oil–water interface, and is known as the dominant determiner of dietary fat digestion. Reducing dietary fat digestion and absorption by modulating the activity of pancreatic lipase has become a favorable strategy to tackle obesity. [...] Read more.

Pancreatic lipase catalyzes the cleavage of triacylglycerols at the oil–water interface, and is known as the dominant determiner of dietary fat digestion. Reducing dietary fat digestion and absorption by modulating the activity of pancreatic lipase has become a favorable strategy to tackle obesity. Orlistat is, at present, the only pancreatic lipase inhibitor approved for the treatment of obesity; however, an array of gastrointestinal adverse effects associated with orlistat limits its tolerability. As a safe alternative to orlistat, a number of natural product-derived compounds with varying degrees of pancreatic lipase inhibitory activity have been reported. We herein reported that bioactivity-guided fractionation of sesame meal led to the identification of free linoleic acid and oleic acid as potent inhibitors of porcine pancreatic lipase in vitro with an IC50 of 23.1 µg/mL (82.4 µM) and 11.7 µg/mL (41.4 µM), respectively. In rats, a single oral dose of the mixture of these fatty acids significantly suppressed the elevation of blood triacylglycerol level following fat intake. These results substantiate the role of free linoleic acid and oleic acid as a novel class of natural product-derived functional molecules that act as pancreatic lipase inhibitors, and their potential for healthy, routine-based weight management. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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Review

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17 pages, 4447 KiB

Open AccessReview

A Review on Gold Nanotriangles: Synthesis, Self-Assembly and Their Applications

by Xiaoxi Yu, Zhengkang Wang, Handan Cui, Xiaofei Wu, Wenjing Chai, Jinjian Wei, Yuqin Chen and Zhide Zhang

Molecules 2022, 27(24), 8766; https://doi.org/10.3390/molecules27248766 - 10 Dec 2022

Cited by 3 | Viewed by 2226

Abstract

Gold nanoparticles (AuNPs) with interesting optical properties have attracted much attention in recent years. The synthesis and plasmonic properties of AuNPs with a controllable size and shape have been extensively investigated. Among these AuNPs, gold nanotriangles (AuNTs) exhibited unique optical and plasmonic properties [...] Read more.

Gold nanoparticles (AuNPs) with interesting optical properties have attracted much attention in recent years. The synthesis and plasmonic properties of AuNPs with a controllable size and shape have been extensively investigated. Among these AuNPs, gold nanotriangles (AuNTs) exhibited unique optical and plasmonic properties due to their special triangular anisotropy. Indeed, AuNTs showed promising applications in optoelectronics, optical sensing, imaging and other fields. However, only few reviews about these applications have been reported. Herein, we comprehensively reviewed the synthesis and self-assembly of AuNTs and their applications in recent years. The preparation protocols of AuNTs are mainly categorized into chemical synthesis, biosynthesis and physical-stimulus-induced synthesis. The comparison between the advantages and disadvantages of various synthetic strategies are discussed. Furthermore, the specific surface modification of AuNTs and their self-assembly into different dimensional nano- or microstructures by various interparticle interactions are introduced. Based on the unique physical properties of AuNTs and their assemblies, the applications towards chemical biology and sensing were developed. Finally, the future development of AuNTs is prospected. Full article

(This article belongs to the Special Issue Design of Molecularly Interfaced Nanostructures for Biological, Environmental and Food Applications)

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