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Special Issue "Recent Development of Mechanochemical Synthesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editors

Guest Editor
Dr. Vjekoslav Štrukil

Ruđer Bošković Institute, Zagreb, Croatia
Website | E-Mail
Interests: mechanochemistry; organic synthesis; green chemistry; solid state photocatalysis; guanidines; (thio)ureas
Guest Editor
Dr. Matej Baláž

Institute of Geotechnics, Slovak Academy of Sciences, Košice, Slovakia
Website | E-Mail
Interests: mechanochemistry; ball milling; materials science; natural materials; environmental chemistry; nanoparticle synthesis; adsorption; solid-state synthesis; eggshell

Special Issue Information

Dear Colleagues,

In order to face the challenges of modern life, chemists around the world are being engaged in a quest for an efficient and practical, yet sustainable, alternative to synthesis in solution. In this respect, mechanochemical synthesis, recognized as an environmentally-friendly methodology, has enabled the implementation of Green Chemistry Principles and is currently going through its renaissance period. Although mechanical milling has been well known as a processing method in inorganic and materials chemistry for decades, its application in other areas of chemical research largely remained unexplored until breakthrough discoveries in solid state reactivity which took place at the turn of the last century. With liquid-assisted, ion and liquid-assisted and polymer-assisted grinding, as powerful tools to enhance and steer the reactivity of molecules in the solid state, mechanochemical synthesis has found its way into fields of supramolecular chemistry and crystal engineering, pharmaceutical science, metal-organic frameworks, and particularly organic chemistry. However, the „older“ branches of mechanochemistry like inorganic synthesis, catalysis or nanomaterials synthesis are still active. The environmental approach is well documented by many publications connecting mechanochemistry and waste treatment, mechanochemical dehalogenation, hydrogen storage or synthesis of advanced materials for various applications (e.g. energy storage and conversion or biomedical applications). The last 15 years have witnessed an enormous progress in solid state mechanochemistry, which has developed from a curiosity into a well-established synthetic methodology. The phenomenon has turned globally, with the number of research groups dealing with different aspects of mechanochemistry growing each year.

This Special Issue of Molecules is devoted to recent developments in this exciting field and is intended to reflect many exciting faces of mechanochemistry. Contributions reporting on the utilization of mechanochemistry for the synthesis of organic and inorganic molecules, cocrystals, metal-organic frameworks, as well as the studies with strong environmental impact (e.g. waste treatment) and mechanochemcial synthesis of advanced materials, including the mechanistic studies on solid state reactions, are welcome. 


Dr. Vjekoslav Štrukil
Dr. Matej Baláž
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mechanochemistry
  • reaction mechanisms
  • organic synthesis
  • crystal engineering
  • metal-organic frameworks
  • green chemistry
  • inorganic synthesis
  • nanomaterials
  • advanced materials synthesis
  • waste treatment

Published Papers (1 paper)

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Open AccessFeature PaperArticle Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives
Molecules 2018, 23(12), 3163; https://doi.org/10.3390/molecules23123163
Received: 15 November 2018 / Revised: 28 November 2018 / Accepted: 29 November 2018 / Published: 30 November 2018
PDF Full-text (12534 KB) | HTML Full-text | XML Full-text | Supplementary Files
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The [...] Read more.
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields. Full article
(This article belongs to the Special Issue Recent Development of Mechanochemical Synthesis)

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