Synthesis and Therapeutic Applications of Iminosugars

Dear Colleagues,

Iminosugars represent the most important class of glycomimetics (carbohydrate analogues) known to date. Because of their excellent ability to modulate the activity of ubiquitous carbohydrate-processing enzymes, iminosugars have been clinically evaluated in a variety of therapeutic areas, ranging from diabetes to viral infections, from malignancies to genetic disorders. The pharmacological potential of iminosugars has prompted the development of a plethora of synthetic approaches, allowing their preparation from laboratory to industrial scales, while enabling the identification of new bioactive candidates with non-natural structures. This issue aims to collect the most recent advances in the synthesis and biological activity of synthetic iminosugars. Original research works or general reviews are welcome, involving innovative synthetic routes to iminosugars, mechanistic insights into their chemical reactivity and/or biological activity, or highlighting novel therapeutic applications.

Dr. Daniele D'Alonzo
Prof. Dr. Annalisa Guaragna
Prof. Dr. Andrea Goti
Guest Editors

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