Advancements in Catalytic Oxidations in Organic Synthesis

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 4973

Special Issue Editors


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Dipartimento di Chimica “Ugo Schiff”, Università degli Studi di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy
Interests: nitrogen-containing glycomimetics; synthesis of natural products and biologically active analogs; multivalency; oxidation reactions; homogeneous catalysis; green chemistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Chemistry “Ugo Schiff”, University of Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy
Interests: nitrogen-containing glycomimetics; new oxidation methods, hypervalent iodine reagents; multivalency; gold glyconanoparticles; glycosidase inhibitors; lysosomal enzymes; pharmacological chaperones; Gaucher–Parkinson relationship
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidations of organic compounds, starting from those employed in the chemical industry on petroleum feedstock, are among the most useful reactions for achieving functional group transformations and installing useful functionalities for further chemical manipulations in products or for imparting desirable physicochemical properties. 

Unfortunately, the classical procedures for the oxidation of organic compounds are at the same time among the less sustainable from many aspects, e.g., the use of stoichiometric metal-based oxidants, toxic and hazardous reagents and solvents, harsh reaction conditions, and production of great amounts of toxic waste. 

In recent years, extensive efforts have been devoted to studying and developing more sustainable methods according to the green chemistry principles, with the aim of increasing atom economy and minimizing the E-factor, while maintaining the high efficiency of the processes. Application of catalysis in its many facets (homogeneous, heterogeneous, catalyst immobilization, biocatalysis, photocatalysis, etc.) has been the key for the success of many proposed processes, particularly for activating and utilizing high economic and friendly oxidants, oxygen and hydrogen peroxide in primis

Nowadays, several sustainable methods are available for producing many different functional groups; however, there is still a continuous need for optimization and generalization and for envisioning more practical procedures.

This issue aims to give a current overview to the most recent advancements in the field.

Prof. Dr. Andrea Goti
Dr. Camilla Matassini
Guest Editors

Manuscript Submission Information

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Keywords

  • Homogeneous oxidations
  • Heterogeneous oxidations
  • Metal catalyzed oxidations
  • Photocatalytic oxidations
  • Enzymatic and biomimetic oxidations
  • Continuous flow oxidations
  • C–H bond oxidation
  • Oxidation of alkenes and alkynes
  • Oxidation of alcohols
  • Oxidation of amines
  • Heteroatom oxidation
  • Oxidation of aromatics and heteroaromatics

Published Papers (3 papers)

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Research

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14 pages, 1613 KiB  
Article
Oxidation of Picoline with Oxygen to Nicotinic Acid against Co2+, NHPI, and Phosphonium or Ammonium Bromides
by Dawid Lisicki, Dorota Talik and Beata Orlińska
Catalysts 2023, 13(9), 1271; https://doi.org/10.3390/catal13091271 - 4 Sep 2023
Viewed by 1201
Abstract
Nicotinic acid (NA) is a heteroaromatic carboxylic acid mainly used as feed, in breakfast cereals, and as a beverage additive. Moreover, it is used as an anti-pellagra drug and as an ingredient in multivitamin supplements. It is manufactured using the Lonza process from [...] Read more.
Nicotinic acid (NA) is a heteroaromatic carboxylic acid mainly used as feed, in breakfast cereals, and as a beverage additive. Moreover, it is used as an anti-pellagra drug and as an ingredient in multivitamin supplements. It is manufactured using the Lonza process from 3-ethyl-3-methylpyridyne as a raw material using HNO3 as the oxidant agent. However, the use of such an oxidant is connected with greenhouse gases, thus making the technology non-ecological. Another industrial process is oxidative ammonolysis of 3-picoline followed by hydrolysis of a reaction intermediate to NA. This paper presents the results of research on the selective oxidation of 3-picoline with oxygen to NA. Bromide organic salts, including ionic liquids, N-hydroxyphtalimide, and cobalt(II) salts, were used as the catalysts. The reaction was carried out with acetic acid (AcOH) as a solvent. The bromide salts imidazolium bromide, quaternary ammonium bromide, and quaternary phosphonium bromide were used. They also fill the role of corrosion inhibitors caused by the acidic and highly oxidative reaction environment. Full article
(This article belongs to the Special Issue Advancements in Catalytic Oxidations in Organic Synthesis)
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Review

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27 pages, 10757 KiB  
Review
Gas-Phase Oxidative Dehydrogenation of n-Octane over Metal Oxide Catalysts: A Review
by Pinkie Ntola and Mzamo Shozi
Catalysts 2024, 14(2), 100; https://doi.org/10.3390/catal14020100 - 25 Jan 2024
Viewed by 1177
Abstract
The oxidative dehydrogenation (ODH) of alkanes, whereby hydrogen is removed to form unsaturated compounds, is an important process, particularly in the petrochemical industry. The ODH of lighter alkanes (C3–C6) is well-reported in the literature, and while there are several reports on the ODH [...] Read more.
The oxidative dehydrogenation (ODH) of alkanes, whereby hydrogen is removed to form unsaturated compounds, is an important process, particularly in the petrochemical industry. The ODH of lighter alkanes (C3–C6) is well-reported in the literature, and while there are several reports on the ODH of n-octane (C8), there is no reported review of the important findings in the literature. This review discusses the gas-phase ODH of n-octane occurring at high temperatures (300–550 °C). The mechanisms via which the n-octane ODH of occurs are also briefly discussed. The oxidants (mainly O2 and CO2) and catalysts (supported and unsupported metal oxides) are discussed as well as the effect of these and the temperature on the type of products formed and their various distributions. Furthermore, the review looks at the acid–base and redox properties of the catalysts and how they affect product formation. Some challenges as well as perspectives of the ODH process are also highlighted. Full article
(This article belongs to the Special Issue Advancements in Catalytic Oxidations in Organic Synthesis)
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71 pages, 50530 KiB  
Review
Copper-Catalyzed/Hypervalent Iodine-Mediated Functionalization of Unactivated Compounds
by Marta Papis, Francesca Foschi, Sara Colombo, Egle Maria Beccalli, Camilla Loro and Gianluigi Broggini
Catalysts 2023, 13(9), 1243; https://doi.org/10.3390/catal13091243 - 26 Aug 2023
Cited by 2 | Viewed by 1855
Abstract
The functionalization of unactivated substrates through the combination of copper catalysts and hypervalent iodine reagents represents a versatile tool in organic synthesis to access various classes of compounds. The hypervalent iodine derivatives can be used simply as oxidizing agents to regenerate the catalytic [...] Read more.
The functionalization of unactivated substrates through the combination of copper catalysts and hypervalent iodine reagents represents a versatile tool in organic synthesis to access various classes of compounds. The hypervalent iodine derivatives can be used simply as oxidizing agents to regenerate the catalytic species or they can associate the functionalization of the starting material. In this review, special attention will be paid to methodologies which provide the introduction of nucleophiles into the reagent by use of suitable benziodoxol(on)es or iodonium salts. Many reactions concern C- and N-arylations, but may also involve formation of different carbon–carbon and carbon–nitrogen bonds, carbon–oxygen as well as carbon–halogen and carbon–phosphorus bonds. Full article
(This article belongs to the Special Issue Advancements in Catalytic Oxidations in Organic Synthesis)
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