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Special Issue "Synthesis and Characterization of Heterocyclic Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 July 2019

Special Issue Editor

Guest Editor
Dr. Carmela Saturnino

Department of Science, The University of Basilicata, Potenza, Italy
Website 1 | Website 2 | E-Mail
Interests: anticancer agents; organo-metal complexes; new antibiotics

Special Issue Information

Heterocyclic compounds, also called heterocycles, are part of a major class of organic chemical compounds characterized by the fact that some or all of the atoms in their molecules are joined in rings containing at least one atom of an element other than carbon (C). Organometallic chemistry plays an important role in modern approaches for the synthesis of heterocycles. Heterocyclic compounds include many of the biochemical materials that are essential to life. Modern society is dependent on synthetic heterocycles for use as drugs with anticancer agents and antibiotics.

This Special Issue of Molecules welcomes submissions of research articles and reviews that concern the design, synthesis and docking studies of new families with potential antitumor and/or antimicrobial activity.

Dr. Carmela Saturnino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic compound/heterocycle
  • cancer
  • organo-metallics
  • antitumor
  • antibacterial
  • antibiotics
  • molecular docking

Published Papers (1 paper)

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Research

Open AccessArticle Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents
Molecules 2019, 24(3), 539; https://doi.org/10.3390/molecules24030539
Received: 13 December 2018 / Revised: 25 January 2019 / Accepted: 26 January 2019 / Published: 1 February 2019
PDF Full-text (1208 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A novel series of thiazole-based heterocycles was synthesized using 1,3-dipolar cycloaddition reactions in the presence of chitosan-grafted-poly(vinylpyridine) as an eco-friendly biopolymeric basic catalyst. The molecular structure of the synthesized compounds was illustrated by spectroscopic and elemental analysis. Various in vitro biological assays were [...] Read more.
A novel series of thiazole-based heterocycles was synthesized using 1,3-dipolar cycloaddition reactions in the presence of chitosan-grafted-poly(vinylpyridine) as an eco-friendly biopolymeric basic catalyst. The molecular structure of the synthesized compounds was illustrated by spectroscopic and elemental analysis. Various in vitro biological assays were performed to explore the potential antitumor, antimicrobial and hepatoprotective activities of the newly synthesized compounds. The cytotoxic activities were assessed against human hepatocellular carcinoma (HepG-2), colorectal carcinoma (HCT-116) and breast cancer (MCF-7) cell lines and results revealed that all compounds displayed antitumor activities with the chlorine-containing derivatives, 11c and 6g, being the most potent. The majority of the tested thiazole derivatives exhibited satisfactory antibacterial activity towards the used gram positive and gram-negative bacterial species. Moreover, many derivatives showed weak hepatoprotective activity against CCl4-induced hepatotoxicity. Full article
(This article belongs to the Special Issue Synthesis and Characterization of Heterocyclic Compounds)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

  1. Author: Janmajoy Banerjee

Affiliation: Sunsari Technical College, Department of Pharmacy, Nepal

  1. Author: Şükriye Güniz Küçükgüzel

Affiliation: Marmara Üniversitesi, Department of Pharmaceutical Chemistry, Istanbul, Turkey

  1. Author: Amira A.E. El-Sayed

Affiliation: Ain Shams University, Department of Chemistry, Cairo, Egypt

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