applsci-logo

Journal Browser

Journal Browser

Advanced Research in Heterocyclic Compounds

A special issue of Applied Sciences (ISSN 2076-3417).

Deadline for manuscript submissions: 20 October 2026 | Viewed by 779

Special Issue Editor

Special Issue Information

Dear Colleagues,

Heterocyclic compounds are extremely important in many areas of science, such as pharmacology, agrochemistry, and materials science, due to their diverse chemical and biological properties. For this reason, advanced research is focused on developing new synthetic methods to create innovative heterocyclic structures, studying their mechanisms of action, and exploring their potential applications. These studies can lead to the design of new drugs, the development of innovative materials, or a better understanding of their roles in biological systems. Therefore, in this Special Issue, research articles and reviews addressing these topics will be accepted, contributing to the advancement of knowledge in this dynamic and promising field.

Dr. Carmela Saturnino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic compounds
  • biological activity
  • medicinal chemistry
  • industrial applications
  • drug development

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1361 KB  
Article
Design, Synthesis and Evaluation of Novel Pyrrolidinone-Based ACE2 Inhibitors: Preliminary Study
by Ilaria Nigro, Maria Francesca Armentano, Anna Caruso, Hussein El-Kashef, Federica Giuzio, Antonio Vassallo, Francesca Finelli, Magnus Monné and Carmela Saturnino
Appl. Sci. 2026, 16(4), 1718; https://doi.org/10.3390/app16041718 - 9 Feb 2026
Viewed by 391
Abstract
This study focuses on the rational design and synthesis of new pyrrolidinone derivatives aimed at inhibiting the ACE2 receptor, a key entry point for SARS-CoV-2. Building on structural insights from known inhibitors like MLN-4760, five compounds featuring a pyrrolidinone core, with some incorporating [...] Read more.
This study focuses on the rational design and synthesis of new pyrrolidinone derivatives aimed at inhibiting the ACE2 receptor, a key entry point for SARS-CoV-2. Building on structural insights from known inhibitors like MLN-4760, five compounds featuring a pyrrolidinone core, with some incorporating indole rings, were synthesized and characterized. Their inhibitory activity against ACE2 was evaluated in vitro, with compound 4 showing the most promising results, further confirmed through cytotoxicity assays and molecular docking studies. Docking analysis revealed favorable binding interactions within the ACE2 active site, supporting the potential of compound 4 as a therapeutic agent. These findings provide a foundation for future in vivo studies and highlight the potential development of novel therapeutics targeting ACE2-related diseases, including COVID-19. Full article
(This article belongs to the Special Issue Advanced Research in Heterocyclic Compounds)
Show Figures

Figure 1

Back to TopTop