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Special Issue "Heterocycles in Supramolecular Chemistry"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 October 2011).

Special Issue Editor

Prof. Dr. Wim Dehaen
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Guest Editor
Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium
Interests: organic synthesis; heterocycles; supramolecular chemistry; porphyrin analogues; natural products; helicenes
Special Issues and Collections in MDPI journals

Keywords

  • molecular recognition
  • hydrogen bonding
  • macrocycles
  • sensing
  • switches
  • membrane transport

Published Papers (2 papers)

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Research

Open AccessArticle
Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
Molecules 2014, 19(7), 9736-9759; https://doi.org/10.3390/molecules19079736 - 08 Jul 2014
Cited by 22
Abstract
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in [...] Read more.
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively. Full article
(This article belongs to the Special Issue Heterocycles in Supramolecular Chemistry)
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Open AccessArticle
Synthesis, Metal Ion Complexation and Computational Studies of Thio Oxocrown Ethers
Molecules 2011, 16(10), 8670-8683; https://doi.org/10.3390/molecules16108670 - 14 Oct 2011
Cited by 11
Abstract
The synthesis of some thio-oxocrown ether ligands, B1 (1,4-dithio-12-crown-4), B2 (1,7-dithio-12-crown-4), B3 (1,7-dithio-15-Crown-5), B4 (1,7-dithio-18-crown-6), B5 (1,10-dithio-18-crown-6), B6 (1,10-dithio-21-crown-7), under mild conditions, were reported. The ligands were characterized by FT-IR, 1H NMR and GC-MS spectroscopy. The formation of 1:1 ligand complexes with [...] Read more.
The synthesis of some thio-oxocrown ether ligands, B1 (1,4-dithio-12-crown-4), B2 (1,7-dithio-12-crown-4), B3 (1,7-dithio-15-Crown-5), B4 (1,7-dithio-18-crown-6), B5 (1,10-dithio-18-crown-6), B6 (1,10-dithio-21-crown-7), under mild conditions, were reported. The ligands were characterized by FT-IR, 1H NMR and GC-MS spectroscopy. The formation of 1:1 ligand complexes with a variety of metal salts (Ag+, Ca+2, K+, Na+, Mg+2, Zn+2 and Fe+2) were investigated by a conductometric method in a 1:1 dioxane–water system at 25 °C, and the complexation constants (Ke = (ΛMAm -Λ) / ((Λ-ΛMaΛbAm) [L]) and free energy (∆Go= - RT lnKe) values are calculated. Details of the specific molecular interactions between the ligands and metals were proposed. We also performed DFT calculations to explain their geometrical properties, charges and frontier molecular orbitals. Full article
(This article belongs to the Special Issue Heterocycles in Supramolecular Chemistry)
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