Special Issue "Glycosides"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (15 December 2010).
Interests: carbohydrates; glycosciences; glycoconjugates; glycosidation; glycolabeling; conformational restriction; thioglycosides; glycopeptides
The progress in analytical sciences during the last decades - especially in the field of NMR spectroscopy - led to a deeper understanding of Glyco-biology and -chemistry. Hence the role of sugars in natural processes had to be rewritten. Primarily they were thought to be nothing more than some storage of chemically bound energy (e.g. starch) or backing structure elements (e.g. cellulose, chitin). However, due to more precise analytical methods, it became evident, that carbohydrates also have crucial allotment in biochemical recognition steps, for example enzyme substrate interactions or cell communication. For this reason the emerging field of Glycoscience quickly became attractive for medicinal research. The main obstacle scientists face today is the difficulty of getting substantial amounts of promising but often very complex Saccharides. Isolating the desired candidates from natural materials is costly and a very demanding process. The synthetic make up of such glycosides is, in all cases a long standing procedure with an immense consumption of resources. Therefore, for the fields of Glyco-biology and -chemistry, there remain unresolved challenges which would play an important role in enhancing biochemical understanding, necessary and valuable for medicinal purpose. This special issue welcomes research articles and comprehensive reviews addressing Glycoscience, reaching from saccharide synthesis and derivatization to biochemical studies on glycosides in general.
Dr. Nikolas Pietrzik
- life sciences
- saccharide synthesis
- saccharide mimetica
- carbohydrate dendrimers
- renewable primary products
- natural products