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Special Issue "ECSOC-13"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 July 2010).

Special Issue Editor

Dr. Julio A. A. Seijas Vázquez
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Guest Editor
Departamento de Química Orgánica, Universidad de Santiago de Compostela, Facultad de Ciencias-Campus de Lugo, Alfonso X el Sabio, 27002 Lugo, SpainPhone: +34 9828 24062Fax: +34 9828 24001
Interests: synthesis of compounds with biologic activity; synthesis of compounds with interest for agro-food field; solation, estructural determination and synthesis of natural products; microwave organic reactions enhancement
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Published Papers (3 papers)

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Open AccessArticle
Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives
Molecules 2010, 15(12), 8973-8987; https://doi.org/10.3390/molecules15128973 - 08 Dec 2010
Cited by 7
Abstract
Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically [...] Read more.
Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed. Full article
(This article belongs to the Special Issue ECSOC-13)
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Open AccessArticle
Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?
Molecules 2010, 15(6), 4283-4293; https://doi.org/10.3390/molecules15064283 - 11 Jun 2010
Cited by 7
Abstract
A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/mL of 87% and 96%, respectively. Those [...] Read more.
A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 µg/mL. Full article
(This article belongs to the Special Issue ECSOC-13)
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Open AccessArticle
Molecular Recognition Studies on Naphthyridine Derivatives
Molecules 2010, 15(3), 1213-1222; https://doi.org/10.3390/molecules15031213 - 03 Mar 2010
Cited by 6
Abstract
The association constants Kb of three hosts IIII designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 15 are reported. 1H-NMR titrations under two different concentration conditions have been employed to [...] Read more.
The association constants Kb of three hosts IIII designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 15 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds. Full article
(This article belongs to the Special Issue ECSOC-13)
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