Special Issue "Natural Product: A Continuing Source of Novel Drug Leads"
Deadline for manuscript submissions: closed (28 February 2017)
Dr. David J. Newman
Retired Chief of Natural Product Branch at the National Cancer Institute at the National Institutes of Health, USA
Phone: +1 610 971 9784
Interests: marine metabolites as drug leads and clinical candidates; marine microbiology; bioinformatics
Natural products are still a major source of drug candidates, potential candidates, and chemical skeletons upon which to perform chemistry. What has become obvious over the last few years is that, in all Kingdoms, the major source of the compound(s) is / are not the host (be it plant, vertebrate, invertebrate or a lower eukaryote), but the microbe(s) that live on, in, or around the "host". With the advent of very fast genomic analyses coupled to state-of-the-art computational systems, the number of BGCs (biosynthetic genomic clusters) is immense, and the number that are involved in the "as yet uncultured microbe" is much larger. Thus, this Special Issue is designed to demonstrate the potential of novel sources as "resources for novel chemistries" with the aim of unlocking more of the novel chemical skeletons in "Mother Nature's Closet".
Dr. David J. Newman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- sources of novel chemical skeletons
- activation of BGCs
- co-culture (natural or artificial)
- cluster analyses