Special Issue "Alkynes: From Reaction Design to Applications in Organic Synthesis"
Deadline for manuscript submissions: closed (30 December 2018)
Prof. Dr. Igor V. Alabugin
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, USA
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Interests: organic reaction mechanisms; stereoelectronic effects; organic photochemistry; DNA photocleavage; carbon-rich materials; chemistry of alkynes; radical chemistry; cyclizations; cycloaromatizations; cycloadditions
Alkyne functionality represents one of the most valuable building blocks of organic chemistry. Despite its seeming simplicity, it combines many unusual and attractive features. For example, the compact carbon-rich alkyne moiety stores >60 kcal/mol of potential energy. Furthermore, alkynes have the same oxidation state as carbonyl compounds and, hence, via simple addition of nucleophiles, offer a “hidden door” entry into carbonyl chemistry. Due to the presence of two independently addressable π-systems, alkynes can readily form four (and, under certain conditions, up to six) new bonds, lending themselves perfectly to the design of cascade transformations. The recent examples of unusual alkyne transformations include ionic chemistry of neutral hydrocarbons, preparation of radicals without radical initiators, generation of excited states without light, "1,2-dicarbene reactivity" of alkynes in "boomerang" radical processes, selective conversion of alkynes into carbonyl compounds, and full disassembly of the alkyne moiety. With the advent of modern catalytic methods, it seems that new reactions of alkynes are discovered every day.
Recognizing the hidden connections between the fundamental features of alkynes and their rich reactivity is essential for uncovering the full potential of this functionality in organic synthesis. The goal of this Special Issue to is to bring multiple examples of new alkyne reactions under one cover to catalyze cross-pollination of ideas for the future development of alkyne chemistry. This issue will contain contributions that cover all aspects of alkyne structure, reactivity, and applications in organic synthesis.
Prof. Dr. Igor V. Alabugin
Manuscript Submission Information
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- cascade transformations