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Molecules 2018, 23(10), 2442; https://doi.org/10.3390/molecules23102442

Acetylene in Organic Synthesis: Recent Progress and New Uses

1
Institute of Chemistry, Saint Petersburg State University, Universitetsky prospect 26, Peterhof 198504, Russia
2
N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky prospect 47, Moscow 119991, Russia
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 14 September 2018 / Accepted: 17 September 2018 / Published: 24 September 2018
(This article belongs to the Special Issue Alkynes: From Reaction Design to Applications in Organic Synthesis)

Abstract

Recent progress in the leading synthetic applications of acetylene is discussed from the prospect of rapid development and novel opportunities. A diversity of reactions involving the acetylene molecule to carry out vinylation processes, cross-coupling reactions, synthesis of substituted alkynes, preparation of heterocycles and the construction of a number of functionalized molecules with different levels of molecular complexity were recently studied. Of particular importance is the utilization of acetylene in the synthesis of pharmaceutical substances and drugs. The increasing interest in acetylene and its involvement in organic transformations highlights a fascinating renaissance of this simplest alkyne molecule. View Full-Text
Keywords: acetylene; vinylation; cross-coupling; addition reactions; drugs; pharmaceutical substances; biologically active molecule; monomers; polymers acetylene; vinylation; cross-coupling; addition reactions; drugs; pharmaceutical substances; biologically active molecule; monomers; polymers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Voronin, V.V.; Ledovskaya, M.S.; Bogachenkov, A.S.; Rodygin, K.S.; Ananikov, V.P. Acetylene in Organic Synthesis: Recent Progress and New Uses. Molecules 2018, 23, 2442.

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