Neuroprotective Potential of Bioactive Natural Compounds in Oxidative Stress Conditions, 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 31339
Special Issue Editors
2. School of Medicine, Catholic University of Croatia, 10000 Zagreb, Croatia
Interests: neuroprotection; neurotoxicity; neurodegenerative diseases; oxidative stress; polyphenols; neuropharmacology
Special Issues, Collections and Topics in MDPI journals
Interests: model membranes; biodegradable nanomaterials; lipid peroxidation; natural products; antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress is one of the major causes of neuronal death in a variety of neurodegenerative diseases. Its contribution to neuropsychiatric disorders has been suggested as well. As the world’s population is getting older, neurodegenerative diseases, such as Alzheimer´s and Parkinson´s disease, represent a growing medical, economic, and social issue. Although considerable progress has been made towards understanding the pathological mechanisms that underlie development and progression of these diseases at the molecular and cellular levels, this knowledge has not yet been successfully translated into the clinics.
Oxidative stress occurs when increased accumulation of reactive oxygen species (ROS) overwhelms the brain’s intrinsic capacity of oxidative defence, leading to detrimental effects on neuronal functioning and viability. Many pieces of evidence indicate that deregulation of metal homeostasis, accompanied with enhanced production of free radicals and increased oxidative stress, could be directly involved in the onset and progression of neurodegenerative diseases. On the other hand, natural products have potential to re-establish redox homeostasis and reduce or prevent metal-induced oxidative damage. They may act as antioxidants, metal chelators and modulators of intracellular signalling. Hence, bioactive natural molecules represent a promising multi-target drug option, particularly at the early stages of neurodegenerative processes.
Therefore, this Special Issue of Molecules is dedicated to research and review articles that cover the latest findings about the beneficial effects of bioactive natural compounds in the prevention and therapy of oxidative stress-driven neuronal injury. Studies devoted to investigation of efficacy and mechanisms of action of various bioactive molecules with the potential to regain metal homeostasis in the treatment of neurodegenerative diseases are particularly welcome.
Dr. Maja Jazvinšćak Jembrek
Dr. Suzana Šegota
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Oxidative stress
- Natural antioxidants
- Neuroprotection
- Metal homeostasis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.