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Special Issue "Microbial Natural Products"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 November 2019

Special Issue Editors

Guest Editor
Dr. Francisco (Paco) Barona-Gomez

Unidad de Genómica Avanzada (Langebio), Mexico City, Mexico
Website | E-Mail
Interests: evolution of metabolic diversity; bacterial genome dynamics and niche adaptation; enzyme evolution; genome-mining tools
Section Board Member
Dr. Cuauhtemoc Licona-Cassani

Centro de Biotecnología FEMSA, Tecnológico de Monterrey, NL, Mexico
E-Mail
Interests: industrial genomics; microbial physiology; actinobacteria; natural products; microbial natural products; genome mining; industrial microbiology
Assistant Guest Editor
Dr. Corina Diana Ceapă

Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
Website | E-Mail
Interests: comparative genomics, host–microbe interactions, novel antibiotics, biotechnological applications

Special Issue Information

Dear Colleagues,

The microbes and the metabolites that they produce have the potential to improve the world in which we live. In particular, the evolution of microbes in various and sometimes extreme environments leads to the apparition of novel functionalities and survival strategies. Natural products discovery has provided the majority of the drugs used in clinics and a large proportion of current industrial enzymes and antibacterials. Natural products, also referred to as secondary or specialized metabolites of bacteria and fungi, are enormously diverse. For instance, it is estimated that only 1% of the diversity inherent to endophytes has so far been explored. In light of the necessity for novel antibiotics, due to a worldwide increase in bacterial resistance, as well as a need for sustainable industrial applications, there remains a strong call for microbial natural products discovery and design. This Special Issue aims to identify and review the latest bioactive compounds that have been discovered and explore the evolutionary driving forces behind the diversification of natural products, as well as their medical, pharmacological, and industrial applications.

Dr. Francisco (Paco) Barona-Gomez
Dr. Cuauhtemoc Licona-Cassani
Dr. Corina Diana Ceapă

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Novel Actinobacteria
  • Secondary metabolites
  • Protein evolution
  • Microbial natural products discovery

Published Papers (2 papers)

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Research

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Open AccessArticle
Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study
Molecules 2019, 24(7), 1331; https://doi.org/10.3390/molecules24071331
Received: 26 February 2019 / Revised: 30 March 2019 / Accepted: 3 April 2019 / Published: 4 April 2019
PDF Full-text (2757 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
As an edible sclerotia-forming fungus, Poria cocos is widely used as a food supplement and as a tonic in China. High-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) was applied to identify triterpene acids in fermented mycelia of P. cocos, as well as the [...] Read more.
As an edible sclerotia-forming fungus, Poria cocos is widely used as a food supplement and as a tonic in China. High-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) was applied to identify triterpene acids in fermented mycelia of P. cocos, as well as the epidermis and inner part of natural sclerotia. A total of 19 triterpene acids were identified in fermented mycelia, whereas 31 were identified in the epidermis and 24 in the inner part. Nine triterpene acids were quantitatively determined, and the concentrations of two valuable triterpenes, dehydropachymic acid and pachymic acid, reached 1.07 mg/g and 0.61 mg/g in the fermented mycelia part, respectively, and were both significantly higher than the concentration in the two natural parts. The fermented mycelia could be a good choice for producing some target triterpene compounds and functional foods through fermentation thanks to the high concentration of some triterpene acids. Full article
(This article belongs to the Special Issue Microbial Natural Products)
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Review

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Open AccessReview
Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications
Molecules 2019, 24(9), 1836; https://doi.org/10.3390/molecules24091836
Received: 28 March 2019 / Revised: 18 April 2019 / Accepted: 23 April 2019 / Published: 13 May 2019
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Abstract
It is well known that terrestrial environments host an immense microbial biodiversity. Exposed to different types of stress, such as UV radiation, temperature fluctuations, water availability and the inter- / intra-specific competition for resources, terrestrial microorganisms have been evolved to produce a large [...] Read more.
It is well known that terrestrial environments host an immense microbial biodiversity. Exposed to different types of stress, such as UV radiation, temperature fluctuations, water availability and the inter- / intra-specific competition for resources, terrestrial microorganisms have been evolved to produce a large spectrum of bioactive molecules. Bacteria, archaea, protists, fungi and algae have shown a high potential of producing biomolecules for pharmaceutical or other industrial purposes as they combine a sustainable, relatively low-cost and fast-production process. Herein, we provide an overview of the different bioactive molecules produced by terrestrial microorganisms with skin protecting applications. The high content in polyphenolic and carotenoid compounds produced by several strains, as well as the presence of exopolysaccharides, melanins, indole and pyrrole derivatives, mycosporines, carboxylic acids and other molecules, are discussed in the context of their antioxidant, photo-protective and skin-whitening activity. Relevant biotechnological tools developed for the enhanced production of high added value natural products, as well as the protecting effect of some antioxidant, hydrolytic and degrading enzymes are also discussed. Furthermore, we describe classes of microbial compounds that are used or have the potential to be used as antimicrobials, moisturizers, biosurfactants, pigments, flavorings and fragrances. Full article
(This article belongs to the Special Issue Microbial Natural Products)
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