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Open AccessArticle

Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

1
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2
Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing 210029, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Francisco (Paco) Barona-Gomez, Cuauhtemoc Licona-Cassani and Corina Diana Ceapă
Molecules 2019, 24(15), 2821; https://doi.org/10.3390/molecules24152821
Received: 16 July 2019 / Revised: 31 July 2019 / Accepted: 31 July 2019 / Published: 2 August 2019
(This article belongs to the Special Issue Microbial Natural Products)
A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide, (+)-neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8,14,24(28)-trien-7-one (3), were isolated and characterized along with five known compounds from the marine-derived fungus Penicillium sp. IMB17-046. The structures of these new compounds were determined using spectroscopic data analyses (HRESIMS, 1D- and 2D-NMR), X-ray crystallography analysis, and TDDFT ECD calculation. Compounds 1 and 3 exhibited broad-spectrum antiviral activities against different types of viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza A virus (IAV), with IC50 values ranging from 0.5 to 7.7 μM. Compounds 1 and 2 showed antibacterial activities against Helicobacter pylori, a causative pathogen of various gastric diseases, with minimum inhibitory concentration (MIC) values of 1–16 μg/mL. View Full-Text
Keywords: marine fungus; Penicillium; pyrazine natural product; antiviral; HIV; influenza A virus; Helicobacter pylori marine fungus; Penicillium; pyrazine natural product; antiviral; HIV; influenza A virus; Helicobacter pylori
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MDPI and ACS Style

Li, J.; Wang, Y.; Hao, X.; Li, S.; Jia, J.; Guan, Y.; Peng, Z.; Bi, H.; Xiao, C.; Cen, S.; Gan, M. Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046. Molecules 2019, 24, 2821.

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