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Open AccessArticle

Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam

1
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, Vietnam
2
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, Vietnam
3
University of Science and Technology of Hanoi (U.S.T.H.), Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, Vietnam
4
Biomedical Science Department, Institute for Research & Executive Education (V.N.U.K.), The University of Danang, 158A Le Loi, Hai Chau District, Danang City 551000, Vietnam
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(21), 3830; https://doi.org/10.3390/molecules24213830
Received: 26 September 2019 / Revised: 17 October 2019 / Accepted: 23 October 2019 / Published: 24 October 2019
(This article belongs to the Special Issue Microbial Natural Products)
Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment Penicillium species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (1), 3-indolecarbaldehyde (2), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3), 2-[(2R-hydroxypropanoyl)amino]benzamide (4), 4-hydroxybenzandehyde (5), chrysogine (6), 3-acetyl-4-hydroxycinnoline (7), acid 1H-indole-3-acetic (8), cyclo (Tyr-Trp) (9), and 2’,3’-dihydrosorbicillin (10). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (3) showed a strong inhibitory effect against Enterococcus faecalis with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2R-hydroxypropanoyl)amino]benzamide (4) and 4-hydroxybenzandehyde (5) selectively inhibited E. coli with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2’,3’-Dihydrosorbicillin (10) potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%). View Full-Text
Keywords: marine fungi Penicillium sp.; 3-acetyl-4-hydroxycinnoline; 4-hydroxybenzandehit; antimicrobiology; α-glucosidase marine fungi Penicillium sp.; 3-acetyl-4-hydroxycinnoline; 4-hydroxybenzandehit; antimicrobiology; α-glucosidase
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MDPI and ACS Style

Le, H.M.T.; Do, Q.T.; Doan, M.H.T.; Vu, Q.T.; Nguyen, M.A.; Vu, T.H.T.; Nguyen, H.D.; Duong, N.T.T.; Tran, M.H.; Chau, V.M.; Pham, V.C. Chemical Composition and Biological Activities of Metabolites from the Marine Fungi Penicillium sp. Isolated from Sediments of Co To Island, Vietnam. Molecules 2019, 24, 3830.

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