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Special Issue "Recent Advances in Natural Products Chemistry Related to Metabolites and Microbiomes"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 9 December 2019

Special Issue Editors

Guest Editor
Dr. Francesco Vinale

Dipartimento di Agraria, Università degli Studi di Napoli Federico II, 80055 Portici (NA), Italy; Istituto per la Protezione Sostenibile delle Piante, Consiglio Nazionale delle Ricerche (IPSP-CNR), 80055 Portici (NA), Italy
Website | E-Mail
Interests: biological control; Trichoderma; secondary metabolites; metabolite characterization; plant pathogens
Guest Editor
Prof. Maria Luisa Balestrieri

Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
Website | E-Mail
Interests: aging; oxidative stress; natural products; betaines; health; bioactive compounds; nitric oxide; endothelial cells; endothelial progenitor cells; angiogenesis; inflammation; cell senescence; apoptosis; atherosclerosis; diabetes; endothelial dysfunction; sirtuins and cardiovascular disease; free radicals; antioxidants; ergothioneine; cell cycle; cancer-related biochemical pathways; cell proliferation; senescence; cancer cell death; epigenetic regulation; sirtuins and cancer

Special Issue Information

Dear Colleagues,

The microbiome is generally referred to as the collective microbial genome found in a particular habitat, while the microbiota is the set of microorganisms living in a specific environment. However, some authors use the term “microbiome” also to indicate the microbes that co-exist within complex communities. In this Special Issue, the term “metabolites” refers only to the small molecules showing important functions in biological processes, with particular emphasis on secondary metabolites. The set of low-molecular-weight metabolites that are produced by organisms is defined as the “metabolome”. The components of the metabolome represent the end products of gene expression and define the biochemical status of an organism.

In the present Special Issue, the following topics will be covered:

  • isolation of novel microbial compounds using metabolomic approaches;
  • molecules and metabolomes related to agricultural applications (crop and animal productions);
  • microbiomes and related natural products with beneficial effects in agriculture;
  • plant metabolites with bioactive properties;
  • influence of beneficial microbes and/or their metabolites on plant metabolomes;
  • microbial metabolites involved in plant or animal interactions;
  • influence of production technologies on animal metabolomes and microbiomes.

Full research papers, reviews, short communications reporting the finding and the characterization of molecules, metabolomes, and related microbiomes and showing their potential for agricultural applications both directly (e.g., increased nutritional value of crops) and indirectly (e.g., effects on the environment, agricultural practices, etc.), as well as their effects on health are invited for this editorial project.


Dr. Francesco Vinale
Prof. Maria Luisa Balestrieri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • secondary metabolites
  • microbial metabolites
  • microbiome
  • metabolome
  • agriculture
  • health benefits

Published Papers (4 papers)

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Research

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Open AccessArticle
Chemical Analysis of Lepidium meyenii (Maca) and Its Effects on Redox Status and on Reproductive Biology in Stallions
Molecules 2019, 24(10), 1981; https://doi.org/10.3390/molecules24101981
Received: 15 March 2019 / Revised: 20 May 2019 / Accepted: 21 May 2019 / Published: 23 May 2019
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Abstract
The present study was conducted to assess the chemical composition of Yellow Maca (Lepidium meyenii) and its biological activity on stallions following oral administration of hypocotyl powder. Maca was subjected to methanolic extraction and the chemical analysis was carried out by [...] Read more.
The present study was conducted to assess the chemical composition of Yellow Maca (Lepidium meyenii) and its biological activity on stallions following oral administration of hypocotyl powder. Maca was subjected to methanolic extraction and the chemical analysis was carried out by LC-MS-QTOF (liquid chromatography-mass spectrometry). Our results showed that Maca contains some effective antioxidants, a high percentage of glucosinolates, and other important components with a high antioxidant capacity. To evaluate the plant biological activity in stallions fed with Maca powder for 60 days, the redox status and some reproductive parameters were investigated. Blood and semen samples were collected at 0, 30, 60, and 90 days from the beginning of this study. Blood samples showed a decrease of the reactive oxygen metabolites, evaluated by d-ROMs test, and an increase of the antioxidant barrier in terms of biological antioxidant potential (BAP test), powerful oxidant capacity (OXY-Adsorbent test), and thiols evaluation (-SHp test). Furthermore, semen samples showed a positive trend during Maca administration in the following parameters: ejaculate volumes and sperm concentrations, total and progressive motility, and acrosome integrity. Full article
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Open AccessArticle
The Issue of Misidentification of Kojic Acid with Flufuran in Aspergillus flavus
Molecules 2019, 24(9), 1709; https://doi.org/10.3390/molecules24091709
Received: 11 April 2019 / Revised: 24 April 2019 / Accepted: 30 April 2019 / Published: 2 May 2019
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Abstract
In the course of investigations on the complex phenomenon of bee decline, Aspergillus flavus was isolated from the haemocoel of worker bees. Observations on the metabolomic profile of this strain showed kojic acid to be the dominant product in cultures on Czapek-Dox broth. [...] Read more.
In the course of investigations on the complex phenomenon of bee decline, Aspergillus flavus was isolated from the haemocoel of worker bees. Observations on the metabolomic profile of this strain showed kojic acid to be the dominant product in cultures on Czapek-Dox broth. However, an accurate review of papers documenting secondary metabolite production in A. flavus also showed that an isomer of kojic acid, identified as 5-(hydroxymethyl)-furan-3-carboxylic acid and named flufuran is reported from this species. The spectroscopic data of kojic acid were almost identical to those reported in the literature for flufuran. This motivated a comparative study of commercial kojic acid and 5-(hydroxymethyl)-furan-3-carboxylic acid, highlighting some differences, for example in the 13C-NMR and UV spectra for the two compounds, indicating that misidentification of the kojic acid as 5-(hydroxymethyl)-furan-3-carboxylic acid has occurred in the past. Full article
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Open AccessArticle
Chlamyphilone, a Novel Pochonia chlamydosporia Metabolite with Insecticidal Activity
Molecules 2019, 24(4), 750; https://doi.org/10.3390/molecules24040750
Received: 14 January 2019 / Revised: 8 February 2019 / Accepted: 14 February 2019 / Published: 19 February 2019
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Abstract
Metabolites from a collection of selected fungal isolates have been screened for insecticidal activity against the aphid Acyrthosiphon pisum. Crude organic extracts of culture filtrates from six fungal isolates (Paecilomyces lilacinus, Pochonia chlamydosporia, Penicillium griseofulvum, Beauveria bassiana, [...] Read more.
Metabolites from a collection of selected fungal isolates have been screened for insecticidal activity against the aphid Acyrthosiphon pisum. Crude organic extracts of culture filtrates from six fungal isolates (Paecilomyces lilacinus, Pochonia chlamydosporia, Penicillium griseofulvum, Beauveria bassiana, Metarhizium anisopliae and Talaromyces pinophilus) caused mortality of aphids within 72 h after treatment. In this work, bioassay-guided fractionation has been used to characterize the main bioactive metabolites accumulated in fungal extracts. Leucinostatins A, B and D represent the bioactive compounds produced by P. lilacinus. From P. griseofulvum and B. bassiana extracts, griseofulvin and beauvericin have been isolated, respectively; 3-O-Methylfunicone and a mixture of destruxins have been found in the active fractions of T. pinophilum and M. anisopliae, respectively. A novel azaphilone compound, we named chlamyphilone, with significant insecticidal activity, has been isolated from the culture filtrate of P. chlamydosporia. Its structure has been determined using extensive spectroscopic methods and chemical derivatization. Full article
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Review

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Open AccessFeature PaperReview
Structures and Bioactive Properties of Myrtucommulones and Related Acylphloroglucinols from Myrtaceae
Molecules 2018, 23(12), 3370; https://doi.org/10.3390/molecules23123370
Received: 2 December 2018 / Revised: 14 December 2018 / Accepted: 17 December 2018 / Published: 19 December 2018
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Abstract
Myrtaceae are a group of plants that include a number of renowned species used in ethnomedicine in many areas worldwide. Their valuable therapeutic properties have stimulated a fruitful research activity addressed to the identification of the bioactive components of their extracts yielding a [...] Read more.
Myrtaceae are a group of plants that include a number of renowned species used in ethnomedicine in many areas worldwide. Their valuable therapeutic properties have stimulated a fruitful research activity addressed to the identification of the bioactive components of their extracts yielding a great diversity of terpenes; polyphenols; and other exclusive products. Among the latter, starting with the discovery of myrtucommulone A from myrtle (Myrtus communis), a series of structurally-related acylphloroglucinol compounds have been characterized from several species that represent the basic active principles to be considered in view of possible drug development. Aspects concerning chemical and biological properties of these products are reviewed in the present paper. Full article
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