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Special Issue "Metallic Nanoparticles: From Synthesis, Structure-Property Relationships to Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 30 August 2019

Special Issue Editors

Guest Editor
Prof. Dr. Frederic Lesage

Biomedical Engineering, Ecloe Polytechnique de Montreal, Montreal, Quebec, Canada
Website | E-Mail
Interests: biomedical engineering; molecular imaging; photoacoustics; nanomaterials design; mathematical modelling; neuronal imaging; optical coherence tomography
Guest Editor
Prof. Dr. Ashok Kakkar

Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, H3A 0B8, Canada
Website | E-Mail
Interests: nanostructures; soft nanoparticles; macromolecules; dendrimers; miktoarm polymers; telodendrimers, naked nanocarriers; metal nanoparticles; gold nanoshells; iron oxide nanoparticles; nanomedicine; drug delivery; diagnostics

Special Issue Information

Dear Colleagues,

Metal nanoparticles continue to play a key role in developing smart nanostructures for applications in a wide variety of areas, including biology. Some of the significant challenges in designing such architectures relate to reproducibility in their synthesis and characterization using a variety of state-of-the-art techniques to develop a detailed understanding of the structure–property relationships, which could translate into higher efficacy in their intended applications. In this Special Issue we aim to develop a comprehensive survey on the recent fabrication and theoretical elaborations of metallic nanoparticles, including Fe, Ag, Au, Zn, Ti; efficacy in their surface functionalization, different methods for characterization to evaluate their unique properties, including electronic, magnetic, electrochemical and optical, and an exploration of their potential for applications in diagnostics, theranostics, sensors, electronic devices, etc. We invite all our colleagues working in the exciting field of nanotechnology to contribute their recent research findings in the format of a communication, full article, as well as reviews.

Prof. Dr. Frédéric Lesage
Prof. Dr. Ashok Kakkar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanotechnology
  • Metallic nanoparticles: Iron, Silver, Gold, Zn and Titanium
  • Characterization of metal nanoparticles
  • Theoretical evaluation
  • Surface functionalization
  • Surface plasmon resonance
  • Surfac enhanced Reyleigh scattering
  • Surfac enhanced Raman scattering
  • Diagnostics
  • Theranostics
  • Sensors
  • Optoelectronics
  • Electronics

Published Papers (5 papers)

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Research

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Open AccessArticle Antimicrobial Potential of Silver Nanoparticles Synthesized Using Medicinal Herb Coptidis rhizome
Molecules 2018, 23(9), 2268; https://doi.org/10.3390/molecules23092268
Received: 11 August 2018 / Revised: 1 September 2018 / Accepted: 5 September 2018 / Published: 5 September 2018
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Abstract
Coptidis rhizome contains several alkaloids that are bioactive agents of therapeutic value. We propose an eco-friendly method to synthesize biocompatible silver nanoparticles (AgNPs) using the aqueous extract of Coptidis rhizome. Silver ions were reduced to AgNPs using the aqueous extract of Coptidis
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Coptidis rhizome contains several alkaloids that are bioactive agents of therapeutic value. We propose an eco-friendly method to synthesize biocompatible silver nanoparticles (AgNPs) using the aqueous extract of Coptidis rhizome. Silver ions were reduced to AgNPs using the aqueous extract of Coptidis rhizome, indicating that Coptidis rhizome can be used for the biosynthesis of AgNPs. The time and the concentration required for conversion of silver ions into AgNPs was optimized using UV-absorbance spectroscopy and inductively coupled plasma spectroscopy (ICP). Biosynthesized AgNPs showed a distinct UV-Visible absorption peak at 420 nm. ICP analysis showed that the time required for the completion of biosynthesis was around 20 min. Microscopic images showed that nanoparticles synthesized were of spherical shape and the average diameter of biosynthesized AgNPs was less than 30 nm. XRD analysis also confirmed the size of AgNps and revealed their crystalline nature. The interaction of AgNPs with phytochemicals present in Coptidis rhizome extract was observed in FTIR analysis. The antimicrobial property of AgNPs was evaluated using turbidity measurements. Coptidis rhizome-mediated biosynthesized AgNPs showed significant anti-bacterial activities against Escherichia coli and Staphylococcus aureus that are commonly involved in various types of infections, indicating their potential as an effective anti-bacterial agent. Full article
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Open AccessArticle Histopathology of the Liver, Kidney, and Spleen of Mice Exposed to Gold Nanoparticles
Molecules 2018, 23(8), 1848; https://doi.org/10.3390/molecules23081848
Received: 19 June 2018 / Revised: 20 July 2018 / Accepted: 24 July 2018 / Published: 25 July 2018
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Abstract
Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched for biomedical applications such as imaging and targeted drug delivery. In this investigation, we studied the effects of a single dose (injected on day 1) as well as a priming dose (two injections
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Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched for biomedical applications such as imaging and targeted drug delivery. In this investigation, we studied the effects of a single dose (injected on day 1) as well as a priming dose (two injections with a gap of one week) of 5 nm, 20 nm, and 50 nm diameter GNPs on the structural and biochemical changes in the liver, kidney, and spleen of mice. The results showed that small sized GNPs (5 nm) produced significant pathological changes in the liver on day 2 that gradually reduced on day 8. The medium (20 nm) and large (50 nm) sized GNPs preferentially targeted the spleen and caused significant pathological changes to the spleen architecture on day 2 that persisted on day 8 as well. There were minimal and insignificant pathological changes to the kidneys irrespective of the GNPs size. The animals that were primed with the pre-exposure of GNPs did not show any aggravation of histological changes after the second dose of the same GNPs. None of the dose regimens of the GNPs were able to significantly affect the markers of oxidative stress including glutathione (GSH) and malondialdehyde (MDA) in all of the organs that were studied. In conclusion, the size of GNPs plays an important role in their pathological effects on different organs of mice. Moreover, the primed animals become refractory to further pathological changes after the second dose of GNPs, suggesting the importance of a priming dose in medical applications of GNPs. Full article
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Open AccessArticle Plate-Focusing Based on a Meta-Molecule of Dendritic Structure in the Visible Frequency
Molecules 2018, 23(6), 1323; https://doi.org/10.3390/molecules23061323
Received: 10 May 2018 / Revised: 22 May 2018 / Accepted: 28 May 2018 / Published: 31 May 2018
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Abstract
To study the potential application of metasurfaces in lens technology, we propose a dendritic meta-molecule surface (also referred to as a dendritic metasurface) and realize the focusing effect in the visible spectrum through simulations and experiments. Using asymmetric dendritic structures, this metasurface can
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To study the potential application of metasurfaces in lens technology, we propose a dendritic meta-molecule surface (also referred to as a dendritic metasurface) and realize the focusing effect in the visible spectrum through simulations and experiments. Using asymmetric dendritic structures, this metasurface can achieve distinct broadband anomalous reflection and refraction. When the metasurface is rotated by 180° around the z axis, anomalous reflection and refraction in vertically incident optical waves are in opposite directions. Considering this feature, a metasurface is designed to achieve a prominent plate-focusing effect. Samples with a transmission peak of green light at 555 nm, yellow light at 580 nm, and red light at 650 nm were prepared using bottom-up electrochemical deposition, and the focus intensity of approximately 10% and focal length of almost 600 µm were experimentally demonstrated. Full article
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Review

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Open AccessFeature PaperReview Synthetic Methodologies to Gold Nanoshells: An Overview
Molecules 2018, 23(11), 2851; https://doi.org/10.3390/molecules23112851
Received: 15 October 2018 / Revised: 27 October 2018 / Accepted: 29 October 2018 / Published: 2 November 2018
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Abstract
Gold nanostructures that can be synthetically articulated to adapt diverse morphologies, offer a versatile platform and tunable properties for applications in a variety of areas, including biomedicine and diagnostics. Among several conformational architectures, gold nanoshells provide a highly advantageous combination of properties that
[...] Read more.
Gold nanostructures that can be synthetically articulated to adapt diverse morphologies, offer a versatile platform and tunable properties for applications in a variety of areas, including biomedicine and diagnostics. Among several conformational architectures, gold nanoshells provide a highly advantageous combination of properties that can be fine-tuned in designing single or multi-purpose nanomaterials, especially for applications in biology. One of the important parameters for evaluating the efficacy of gold nano-architectures is their reproducible synthesis and surface functionalization with desired moieties. A variety of methods now exist that allow fabrication and chemical manipulation of their structure and resulting properties. This review article provides an overview and a discussion of synthetic methodologies to a diverse range of gold nanoshells, and a brief summary of surface functionalization and characterization methods employed to evaluate their overall composition. Full article
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Open AccessReview Bactericidal Properties of Plants-Derived Metal and Metal Oxide Nanoparticles (NPs)
Molecules 2018, 23(6), 1366; https://doi.org/10.3390/molecules23061366
Received: 27 April 2018 / Revised: 12 May 2018 / Accepted: 15 May 2018 / Published: 6 June 2018
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Abstract
Nanoparticles (NPs) are nano-sized particles (generally 1–100 nm) that can be synthesized through various methods. The wide range of physicochemical characteristics of NPs permit them to have diverse biological functions. These particles are versatile and can be adopted into various applications, particularly in
[...] Read more.
Nanoparticles (NPs) are nano-sized particles (generally 1–100 nm) that can be synthesized through various methods. The wide range of physicochemical characteristics of NPs permit them to have diverse biological functions. These particles are versatile and can be adopted into various applications, particularly in biomedical field. In the past five years, NPs’ roles in biomedical applications have drawn considerable attentions, and novel NPs with improved functions and reduced toxicity are continuously increasing. Extensive studies have been carried out in evaluating antibacterial potentials of NPs. The promising antibacterial effects exhibited by NPs highlight the potential of developing them into future generation of antimicrobial agents. There are various methods to synthesize NPs, and each of the method has significant implication on the biological action of NPs. Among all synthetic methods, green technology is the least toxic biological route, which is particularly suitable for biomedical applications. This mini-review provides current update on the antibacterial effects of NPs synthesized by green technology using plants. Underlying challenges in developing NPs into future antibacterials in clinics are also discussed at the present review. Full article
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