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Special Issue "Cinnamic Acids and Analogs: Food and Health Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editors

Assoc. Prof. Dr. Fernanda Borges
E-Mail Website
Guest Editor
Faculty of Pharmacy, University of Porto, Portugal
Interests: Drug discovery; Nanomedicine; ADME-Tox; Neurodegenerative; Liver and infectious diseases; Antioxidants
Dr. Jorge Garrido
E-Mail Website
Guest Editor
Department of Chemical Engineering, School of Engineering (ISEP), Polytechnic of Porto, Portugal
Interests: Analytical methods; Electroanalysis; Nanotechnology; Bioactive compounds
Dr. Tiago Barros Silva
E-Mail Website
Guest Editor
CNC/Center for Neurosciences and Cell Biology, UCBiotech, Coimbra
Interests: COMT; Heterocycle catechol mimics; Neuroprotection; Dual-target drugs

Special Issue Information

Dear Colleagues,

Cinnamic acids (CAs) are a remarkable class of secondary metabolites ubiquitously distributed across multiple sources in nature. The chemical scaffold of CAs can be found in a vast number of naturally-occurring and synthetic bioactive molecules, which makes it a privileged structure for food applications and drug discovery. The academic community has become increasingly interested in studying the effects of Cas, discovering promising bioactivities that go beyond their established role as antioxidants. In this context, CAs may provide a versatile chemical building block to develop safe and low-cost functional foods, nutraceuticals, additives, and drug candidates for therapy. This Special Issue aims to provide a multidisciplinary platform for scientists to publish reviews or original research concerning CAs and derivatives thereof. From the study and analysis of natural sources to the development of drug-like synthetic derivatives, we encourage contributions on all aspects of the chemistry and bioactivity of CAs that make substantial advances within this field.

Prof. Fernanda Borges
Prof. Jorge Garrido
Dr. Tiago Barros Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access Biannual journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cinnamic acids
  • Bioactivity
  • Analysis
  • Natural products
  • Phytochemicals
  • Functional food
  • Nutraceuticals
  • Additives
  • Drug discovery
  • Food applications
  • Health applications

Published Papers (1 paper)

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Research

Open AccessFeature PaperArticle
Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues
Molecules 2019, 24(23), 4405; https://doi.org/10.3390/molecules24234405 - 02 Dec 2019
Abstract
Exogenous antioxidants may be beneficial therapeutic tools to tackle the oxidative damage in neurodegenerative diseases by regulation of the redox state that is critical for cell viability and organ function. Inspired by natural plant polyphenols, a series of cinnamic acid-based thiophenolic and phenolic [...] Read more.
Exogenous antioxidants may be beneficial therapeutic tools to tackle the oxidative damage in neurodegenerative diseases by regulation of the redox state that is critical for cell viability and organ function. Inspired by natural plant polyphenols, a series of cinnamic acid-based thiophenolic and phenolic compounds were synthesized and their antioxidant and neuroprotective properties were studied. In general, our results showed that the replacement of the hydroxyl group (OH) by a sulfhydryl group (SH) increased the radical scavenging activity and enhanced the reaction rate with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and galvinoxyl radical (GO). These results correlated well with the lower oxidation potential (Ep) values of thiophenols. However, a lower peroxyl radical (ROO) scavenging activity was observed for thiophenols in oxygen radical absorbance capacity (ORAC-FL) assay. Furthermore, the introduction of 5-methoxy and 5-phenyl groups in the aromatic ring of 4-thioferulic acid (TFA) 2 and ferulic acid (FA) 1 did not significantly improve their antioxidant activity, despite the slight decrease of Ep observed for compounds 5, 6, and 9. Concerning cinnamic acid amides, the antioxidant profile was similar to the parent compounds. None of the compounds under study presented significant cytotoxic effects in human differentiated neuroblastoma cells. Thiophenolic amide 3 stands out as the most promising thiophenol-based antioxidant, showing cellular neuroprotective effects against oxidative stress inducers (hydrogen peroxide and iron). Full article
(This article belongs to the Special Issue Cinnamic Acids and Analogs: Food and Health Applications)
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