Chemical Modification of Functional Proteins for Diseases Detection and Treatment
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 13215
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent decades, chemical protein modification has become a blooming field of study. Driven by the rapid development of novel bioconjugation chemistry, researchers are now able to conjugate desired targets on many natural amino acids. State-of-the-art biorthogonal chemistries have further enhanced the site selectivity of protein modification, leading to the creation of new and remarkable functions on native proteins, the targeted delivery of functional proteins, the creation of unnatural post-translational modifications, and the assembly of multifunctional protein-based nanostructures and biopolymers that have been used in both in vitro and in vivo applications. With this vast array of invaluable tools, researchers can design and develop novel therapeutics that can be approved by the FDA and enter the market, such as PEGylated proteins and antibody–drug conjugates.
In this Special Issue, we will focus on the recently developed methodologies in the chemical modification of proteins, covering bioconjugation reactions, ligation chemistries, and bio-orthogonal chemistries that turn ordinary natural proteins into therapeutics. We will also highlight some of the novel examples and applications of these chemically modified proteins that were used in recent biomedical research. Researchers are welcome to contribute any work dedicated to the design, synthesis, and therapeutic evaluation of chemically modified proteins.
Dr. Clarence T. T. Wong
Guest Editor
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Keywords
- chemical protein modification
- protein conjugation
- therapeutic proteins
- drug–protein conjugate
- protein probes
- protein delivery
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