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Article

Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells

Section of Experimental Oncology und Nanomedicine (SEON), ENT-Department, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
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Molecules 2019, 24(14), 2588; https://doi.org/10.3390/molecules24142588
Received: 20 May 2019 / Revised: 11 July 2019 / Accepted: 14 July 2019 / Published: 16 July 2019
(This article belongs to the Special Issue Cardiovascular Nanomedicines and Nanomaterials )
Magnetic drug targeting utilizes an external magnetic field to target superparamagnetic iron oxide nanoparticles (SPIONs) and their cargo to the diseased vasculature regions. In the arteries, the flow conditions affect the behavior of magnetic particles and the efficacy of their accumulation. In order to estimate the magnetic capture of SPIONs in more physiological-like settings, we previously established an ex vivo model based on human umbilical cord arteries. The artery model was employed in our present studies in order to analyze the effects of the blood components on the efficacy of magnetic targeting, utilizing 2 types of SPIONs with different physicochemical characteristics. In the presence of freshly isolated human plasma or whole blood, a strong increase in iron content measured by AES was observed for both particle types along the artery wall, in parallel with clotting activation due to endogenous thrombin generation in plasma. Subsequent studies therefore utilized SPION suspensions in serum and washed red blood cells (RBCs) at hematocrit 50%. Interestingly, in contrast to cell culture medium suspensions, magnetic accumulation of circulating SPION-3 under the external magnet was achieved in the presence of RBCs. Taken together, our data shows that the presence of blood components affects, but does not prevent, the magnetic accumulation of circulating SPIONs. View Full-Text
Keywords: SPIONs; magnetic targeting; nanoparticle accumulation; ex vivo flow model; blood cells SPIONs; magnetic targeting; nanoparticle accumulation; ex vivo flow model; blood cells
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MDPI and ACS Style

Hennig, T.L.; Unterweger, H.; Lyer, S.; Alexiou, C.; Cicha, I. Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells. Molecules 2019, 24, 2588. https://doi.org/10.3390/molecules24142588

AMA Style

Hennig TL, Unterweger H, Lyer S, Alexiou C, Cicha I. Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells. Molecules. 2019; 24(14):2588. https://doi.org/10.3390/molecules24142588

Chicago/Turabian Style

Hennig, Till L., Harald Unterweger, Stefan Lyer, Christoph Alexiou, and Iwona Cicha. 2019. "Magnetic Accumulation of SPIONs under Arterial Flow Conditions: Effect of Serum and Red Blood Cells" Molecules 24, no. 14: 2588. https://doi.org/10.3390/molecules24142588

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