Cardiovascular Nanomedicine
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 619
Special Issue Editors
Interests: cardiovascular physiology & pharmacology; renin-angiotensin system (RAS); local blood flow control; hypersensititvity reaction (HSR); nanomedicines; complement; CARPA
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; magnetic nanoparticles; drug delivery; biomaterials; biofabrication; vascular biology; hemorheology
Special Issues, Collections and Topics in MDPI journals
Interests: adverse drug effects; anaphylactic shock; animal models; immune toxicity; immunogeneicity; nanomedicines; (pseudo)allergy
Special Issue Information
Dear Colleagues,
Cardiovascular nanomedicine (CVN) is a rapidly expanding field of medical nanotechnology. Nanoparticle (NP)-based drugs and diagnostic agents are now routinely utilized in clinical settings. One of the main advantages of nanoparticle-based agents is the controlled and targeted delivery to diseased tissues. Thus, efficacy is increased and classical side-effects are reduced. However, unexpected side-effects, mostly hypersensitivity reactions (HSRs) that also represent regulatory issues, appear. Among HSRs, complement-activation-related pseudoallergy (CARPA) is one with special human relevance.
Cardiovascular diseases (CVDs) are the most significant health problem in the world. Diseases of the heart as well as the vascular system belong to this discipline. While treatment with nanomedicines is well established for oncological and systemic fungal diseases, CVN is still the route ahead. Various NPs have been used for improving the features of existing CVD medications, while others for controlled delivery of new drugs. Another approach is to develop NP-based diagnostic agents for CVDs, e.g., superparamagnetic iron oxide nanoparticles (SPIONs) for plaques. However, most of these activities are still in the preclinical or early clinical trial phase. There is still long way to go before translational research can implement new CVD therapeutic and diagnostic strategies into clinical practice, and both efficacy and safety issues will first need to be addressed.
This Special Issue of Nanomaterials invites original research articles as well as review articles that will stimulate the continuing efforts in this exciting and continuously expanding field.
Dr. László Dézsi
Dr. Iwona Cicha
Prof. Dr. János Szebeni
Guest Editors
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Keywords
- Cardiovascular nanomedicine
- Cardiovascular disease
- Nanoparticle design
- SPIONs
- Controlled delivery
- Diagnostic agents
- Clinical translation
- Nanosafety
- Hypersensitive reactions
- Regulatory issues
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