Cutting-Edge Developments in Antimicrobial Drug Discovery and Design
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 18
Special Issue Editors
Interests: biocatalysis; biotransformation; stereoselective synthesis; natural products; biological activity of compounds
Special Issues, Collections and Topics in MDPI journals
Interests: flavonoid; natural compounds; biological activity; anticancer activity; antioxidant activity; chalcone; multidrug-resistant pathogens; food science; antimicrobial agents; cytotoxicity assays; amyloid; Crohn’s disease; AIEC; biofilm
Special Issues, Collections and Topics in MDPI journals
Interests: enzymatic catalysis; biotransformation; organic synthesis; isolation natural products; chemistry of cosmetic
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the present day, the growing multi-drug resistance of pathogenic strains of bacteria and fungi, along with their ability to form biofilms, poses a problem of significant clinical importance. This phenomenon leads to a reduction in the effectiveness of conventional drugs, ultimately resulting in increased mortality rates. Consequently, it is crucial to continuously search for new molecules with antimicrobial activity or modify existing therapeutic strategies.
In this Special Edition, we welcome experimental studies as well as literature reviews that showcase innovative approaches to the design of new antimicrobial drugs. These can encompass various aspects, ranging from the application of advanced technologies such as artificial intelligence to the exploration of natural bioactive compounds. Therefore, the scope of the research topics may include areas such as:
- Utilization of computational chemistry and molecular modeling in drug design,
- The application of biotechnology in the production of molecules with antimicrobial properties,
- Identification of new natural compounds with antimicrobial effects, such as peptides or other substances produced by microorganisms or plants,
- Structural modifications of known antimicrobial compounds,
- Potential anti-biofilm agents,
- Synergy between known antibiotics and natural compounds, essential oils, extracts, etc.,
- Nanomaterials and other novel drug carriers,
- Vaccines, phage therapies, and other immunotherapies to enhance the patient's immune system.
We hope that the publications featured in this issue will contribute significantly to reducing the burden of infectious diseases in modern society and addressing the phenomenon of resistance to currently known antimicrobial agents.
Dr. Wanda Mączka
Dr. Anna Duda-Madej
Prof. Dr. Katarzyna Wińska
Guest Editors
Manuscript Submission Information
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Keywords
- antimicrobial activity
- multidrug resistance
- antibiotic resistance
- pathogenic strains
- phytochemicals
- organic synthesis
- computational drugs design
- molecular modeling
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